Does Helicobacter pylori colonize the gastric mucosa of Meckel's diverticulum?
Does Helicobacter pylori colonize the gastric mucosa of Meckel's diverticulum?
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幽门螺杆菌是否定植于梅克尔憩室的胃粘膜？
DOI：
10.1016/s0025-6196(12)65013-7
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发表时间：
1990
影响因子：
8.9
通讯作者：
Phillips,SF
中科院分区：
文献类型：
--
作者：
Fich,A;Talley,NJ;Shorter,RG;Phillips,SF
幽门螺杆菌（以前，幽门弯曲杆菌）是一种高度适应的生物，似乎只感染胃型粘膜。在本研究中，我们试图确定远离胃的胃上皮，即梅克尔憩室的异位胃黏膜，是否容易被h定植。幽门。回顾性地，我们检查了23例切除含有异位胃粘膜的梅克尔憩室的患者的活检标本。作为方法学上的对照，我们也回顾了18例接受前切除术的慢性十二指肠溃疡患者的胃窦活检标本。Meckel憩室异位胃粘膜为窦型13例，基底型10例。6例患者憩室溃疡。异位胃黏膜未发现慢性或活动性慢性胃炎的证据。幽门未在任何梅克尔憩室中发现，但在89%的十二指肠溃疡患者的胃窦中存在幽门。这些结果表明。幽门螺杆菌可能不会在梅克尔憩室的异位胃粘膜上定植，并且在该部位溃疡的发生中没有作用。
Helicobacter pylori (formerly,Campylobacterpylori) is a highly adapted organism that seems to infect only gastric-type mucosa. In this study, we attempted to determine whether gastric epithelium at a site distant from the stomach, the heterotopic gastric mucosa of Meckel's diverticulum, was susceptible to colonization byH. pylori.Retrospectively, we examined biopsy specimens from 23 patients who had undergone resection of Meckel's diverticulum that contained heterotopic gastric mucosa. As a methodologic control, we also reviewed antral biopsy specimens from 18 patients with chronic duodenal ulcer who had undergone antrectomy. Heterotopic gastric mucosa in Meckel's diverticulum was of antral type in 13 patients and fundic type in 10 patients. Six patients had an ulcer in the diverticulum. No evidence of chronic or active chronic gastritis was detected in the heterotopic gastric mucosa.H. pyloriwas not found in any Meckel's diverticula but was present in the antrum of 89% of patients with duodenal ulcer. These results suggest thatH. pylorimay not colonize the heterotopic gastric mucosa of Meckel's diverticulum and has no role in the development of ulceration at this site.