Tumor necrosis factor-α mediates one component of competitive, experience-dependent plasticity in developing visual cortex
Tumor necrosis factor-α mediates one component of competitive, experience-dependent plasticity in developing visual cortex
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DOI：
10.1016/j.neuron.2008.04.023
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发表时间：
2008-06-12
期刊：
影响因子：
16.2
通讯作者：
Stryker, Michael P.
中科院分区：
文献类型：
--
作者：
Kaneko, Megumi;Stellwagen, David;Stryker, Michael P.
视觉皮层发育中的快速、经验依赖性可塑性被认为是有竞争力的。单眼视觉剥夺后，双眼神经元对一只眼睛的反应减少，而对另一只眼睛的反应相应增加。在TNF α缺乏的小鼠中的慢性光学成像揭示了剥夺眼反应的正常初始损失，但随后对睁开眼的反应增加是不存在的。该突变还在体外阻断了mEPSC在视觉皮层中的稳态突触缩放，而不影响LTP。在单眼皮层，被认为是不受竞争，在TNF α突变体的反应是减少在双眼区。野生型小鼠内源性TNF α的药理学抑制与基因敲除表型相似。这些研究结果表明，在视觉皮层发育中的经验依赖性竞争是两个不同的，非竞争性过程的结果，剥夺眼反应的损失，然后是依赖于TNF α信号的反应的明显稳态增加。
Rapid, experience-dependent plasticity in developing visual cortex is thought to be competitive. After monocular visual deprivation, the reduction in response of binocular neurons to one eye is matched by a corresponding increase to the other. Chronic optical imaging in mice deficient in TNF alpha reveals the normal initial loss of deprived-eye responses, but the subsequent increase in response to the open eye is absent. This mutation also blocks homeostatic synaptic scaling of mEPSCs in visual cortex in vitro, without affecting LTP. In monocular cortex, thought not to be subject to competition, responses in TNF alpha mutants are as reduced as in the binocular zone. Pharmacological inhibition of endogenous TNF alpha in wild-type mice phenocopies the knockout. These findings suggest that experience-dependent competition in developing visual cortex is the outcome of two distinct, noncompetitive processes, a loss of deprived-eye responses followed by an apparently homeostatic increase in responses dependent on TNF alpha signaling.