Corticotropin-releasing activity of monokines.
Corticotropin-releasing activity of monokines.
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单核因子的促肾上腺皮质激素释放活性。
DOI：
10.1126/science.2997929
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Blalock,JE
中科院分区：
文献类型：
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作者：
Woloski,BM;Smith,EM;Meyer3rd,WJ;Fuller,GM;Blalock,JE
肝细胞刺激因子和白细胞介素-1是由单核细胞响应炎症激发而产生的蛋白质。这两种单核因子对培养的肾上腺皮质细胞产生类固醇激素都没有直接影响。这两种单核细胞因子刺激垂体细胞（AtT-20）释放促肾上腺皮质激素;白细胞介素-1与促肾上腺皮质激素释放因子和精氨酸加压素的组合是等效的，肝细胞刺激因子至少是有效的三倍。人工合成的糖皮质激素地塞米松可抑制培养的单核细胞产生肝细胞刺激因子。这些结果表明，单核细胞和垂体和肾上腺皮质细胞之间的轴，这可能在调节宿主防御的作用。
Hepatocyte-stimulating factor and interleukin-1 are proteins produced by monocytes in response to inflammatory challenge. Neither of these monokines had direct effects on steroid production by cultured adrenocortical cells. Both monokines stimulated pituitary cells (AtT-20) to release adrenocorticotropic hormone; interleukin-1 was equipotent with a combination of corticotropin-releasing factor and arginine vasopressin, and hepatocyte-stimulating factor was at least three times as effective. The synthetic glucocorticoid, dexamethasone, inhibited production of hepatocyte-stimulating factor by cultured monocytes. These results indicate an axis between monocytes and pituitary and adrenocortical cells which may play a role in regulating host defense.