Serum levels of CXCR3 ligands predict T cell-mediated acute rejection after kidney transplantation
Serum levels of CXCR3 ligands predict T cell-mediated acute rejection after kidney transplantation
复制标题
CXCR3配体的血清水平预测肾移植后T细胞介导的急性排斥反应
DOI：
10.3892/mmr.2013.1753
复制
发表时间：
2014-01-01
影响因子：
3.4
通讯作者：
Shi, Bingyi
中科院分区：
文献类型：
--
作者：
Huang, Haiyan;Xu, Xiaoguang;Shi, Bingyi
急性排斥反应的早期诊断对肾移植术后移植物存活至关重要。干扰素- (IFN)- cxcr3趋化因子依赖性炎症环在急性排斥反应中T淋巴细胞募集中起关键作用。以前发表的研究通常集中在CXCR3受体上，而不是其配体上。在本研究中，我们使用Luminex检测异体肾移植受者血清中CXCR3配体、IFN诱导的单因子（MIG）、IFN诱导的蛋白10 （IP-10）和IFN诱导的t细胞化学引诱剂（I-TAC）的水平。根据肾移植后一个月进行的肾活检，32名受者被诊断为T细胞介导的急性排斥反应，38名患者被评估为稳定。在诊断急性排斥反应后或移植后1个月采集血清。急性排斥反应时血清中MIG（中位数，4271 pg/ml）、IP-10（中位数，686.7 pg/ml）和I-TAC（中位数，44.32 pg/ml）浓度显著高于稳定组(MIG， P=0.0002; IP-10， P=0.0001; I-TAC， P=0.0103
The early diagnosis of acute rejection is crucial for graft survival after kidney transplantation. The interferon- (IFN)-CXCR3-chemokine-dependent inflammatory loop plays a pivotal role in the recruitment of T lymphocytes during acute rejection. Previously published studies have typically focused on the CXCR3 receptor rather than on its ligands. In the present study, we used Luminex assays to detect the levels of CXCR3 ligands, monokine induced by IFN (MIG), IFN-induced protein 10 (IP-10) and IFN-induced T-cell chemoattractant (I-TAC), in the serum of renal allograft recipients. According to a renal biopsy performed one month after kidney transplantation, 32 recipients were diagnosed with T cell-mediated acute rejection and 38 patients were evaluated as stable. Serum was collected after the diagnosis of acute rejection or one month after transplantation. The concentrations of MIG (median, 4,271 pg/ml), IP-10 (median, 686.7 pg/ml) and I-TAC (median, 44.32 pg/ml) in the serum during an acute rejection episode were significantly higher compared with those of the stable patients (MIG, P=0.0002; IP-10, P=0.0001; I-TAC, P=0.0103; vs. the stable function group, P