CYTO-TOXIC T-CELLS RECOGNIZE FRAGMENTS OF THE INFLUENZA NUCLEOPROTEIN
CYTO-TOXIC T-CELLS RECOGNIZE FRAGMENTS OF THE INFLUENZA NUCLEOPROTEIN
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DOI：
10.1016/0092-8674(85)90103-5
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发表时间：
1985-01-01
期刊：
影响因子：
64.5
通讯作者：
DAVEY, J
中科院分区：
文献类型：
--
作者：
TOWNSEND, ARM;GOTCH, FM;DAVEY, J
最近的研究表明，大部分鼠甲型流感特异性细胞毒性 T 淋巴细胞 (CTL) 能够识别病毒核蛋白。为了研究CTL识别病毒的这种非糖蛋白成分的机制，对A病毒NP基因的一系列缺失突变体进行了研究。结果表明CTL识别NP分子的三个不同表位。蛋白质的 N 端和 C 端片段彼此独立地转运至 CTL 识别的位点。这些发现表明，可能存在一种将缺乏明确信号序列的病毒蛋白和蛋白片段转运至细胞表面并呈递至 CTL 的机制。
Recent work has shown that a major population of murine influenza A specific cytotoxic T lymphocytes (CTL) recognize the viral nucleoprotein. In order to investigate the mechanism by which this nonglycoprotein component of the virus is recognized by CTL, a series of deletion mutants of an A virus NP gene were studied. The result showed that CTL recognize three distinct epitopes of the NP molecule. Both N- and C-terminal fragment of the protein are transported, independently of each other, to the site of recognition by CTL. These findings imply that a mechanism may exist for transport to the cell surface and presentation to CTL, of viral proteins and protein fragments that lack defined signal sequences.