Random Cell Motion Enhances the Capacity of Cell-Cell Communication
Random Cell Motion Enhances the Capacity of Cell-Cell Communication
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DOI：
10.1109/tmbmc.2020.2983909
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发表时间：
2019-11
期刊：
影响因子：
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通讯作者：
T. Nakano;Lin Lin-Lin;Yutaka Okaie;Cong Wu;Hao Yan;T. Hara;K. Harumoto
中科院分区：
文献类型：
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作者：
T. Nakano;Lin Lin-Lin;Yutaka Okaie;Cong Wu;Hao Yan;T. Hara;K. Harumoto
细胞通过信号分子的传输和接收来相互通信。在本文中，我们检验了随机细胞运动可以增强细胞间通讯的假设。我们首先进行细胞跟踪实验以获得内皮细胞的运动参数，然后使用分子通信框架来获得细胞可实现的通信速率。我们的结果表明，当细胞使用的信号分子比众所周知的血管内皮生长因子的扩散性低一个数量级时，随机细胞运动可以有利于细胞间通讯。
Cells communicate with each other via the transmission and reception of signal molecules. In this paper, we test our hypothesis that random cell motion can enhance cell-cell communication. We first conducted cell-tracking experiments to obtain motility parameters of endothelial cells, and then used the molecular communication framework to obtain the achievable rates at which cells can communicate. Our results show that random cell motion can benefit cell-cell communication when signal molecules that cells use are an order of magnitude less-diffusive than well-known vascular endothelial growth factors.