RESPIRATION DURING SLEEP IN NORMAL MAN
RESPIRATION DURING SLEEP IN NORMAL MAN
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DOI：
10.1136/thx.37.11.840
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发表时间：
1982-01-01
期刊：
影响因子：
10
通讯作者：
ZWILLICH, CW
中科院分区：
文献类型：
--
作者：
DOUGLAS, NJ;WHITE, DP;ZWILLICH, CW
对19名健康成人在清醒和睡眠时的呼吸量和呼吸时间进行了测量。在睡眠的所有阶段，每分钟通气量显著低于（P <0.05）受试者清醒时（7.66 ± 0.05）。0.34[SEM [平均值的标准误差]] l/min），快速眼动（REM）睡眠中的水平（6.46 ±. 0.29 l/min）显著低于非快速眼动睡眠（7.18 ±. 0.39 l/min）。在睡眠的所有阶段的呼吸模式是显着更快，更浅，比清醒时，在REM睡眠潮气量被减少到73%的清醒时的水平。平均吸气流速（VT/Ti），吸气驱动的指数，在REM睡眠中显着低于清醒或非REM睡眠。睡眠期间通气量下降，最大的减少发生在REM睡眠期间，此时吸气驱动力平行减少。在正常人和慢性阻塞性肺疾病患者中，类似的通气变化可能导致REM相关的低氧血症。
Respiratory volumes and timing were measured in 19 healthy adults during wakefulness and sleep. Minute ventilation was significantly less (P < 0.05) in all stages of sleep than when the subject was awake (7.66 .+-. 0.34 [SEM [standard error of the mean]] l/min), the level in rapid-eye-movement (REM) sleep (6.46 .+-. 0.29 l/min) being significantly lower than in non-REM sleep (7.18 .+-. 0.39 l/min). The breathing pattern during all stages of sleep was significantly more rapid and shallow than during wakefulness, tidal volume in REM sleep being reduced to 73% of the level during wakefulness. Mean inspiratory flow rate (VT/Ti), an index of inspiratory drive, was significantly lower in REM sleep than during wakefulness or non-REM sleep. Ventilation falls during sleep, the greatest reduction occurring during REM sleep, when there is a parallel reduction in inspiratory drive. Similar changes in ventilation may contribute to the REM-associated hypoxemia in normal subjects and in patients with chronic obstructive pulmonary disease.