Facile Synthesis of γ-Butenolides and Maleic Anhydrides via Annulation of α-Keto Acids and Triazenyl Alkynes
Facile Synthesis of γ-Butenolides and Maleic Anhydrides via Annulation of α-Keto Acids and Triazenyl Alkynes
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DOI：
10.1021/acs.joc.1c02727
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发表时间：
2022-03-04
影响因子：
3.6
通讯作者：
Cui, Sunliang
中科院分区：
文献类型：
--
作者：
Bao, Xiaodong;Zeng, Linwei;Cui, Sunliang
介绍了一种通过α-酮酸和三氮烯基炔的环化反应合成γ-丁烯内酯和马来酸酐的简便方法。在该反应中，α-酮酸与三氮烯基炔在室温下发生自催化成环反应，生成γ-丁烯内酯，而BF_3-Et_2O进一步加成生成马来酸酐。总的来说，这些方法具有反应条件温和，范围广，效率高。
A facile synthesis of gamma-butenolides and maleic anhydrides via annulation of alpha-keto acids and triazenyl alkynes is described. In this process, alpha-keto acids and triazenyl alkynes could undergo a self-catalyzed annulation at room temperature to deliver gamma-butenolides efficiently, while the further addition of BF3-Et2O furnished maleic anhydrides. Overall, these processes have mild reaction conditions, broad scope, and high efficiency.