Polypeptide Globular Adiponectin Ameliorates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Necroptosis.
Polypeptide Globular Adiponectin Ameliorates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Necroptosis.
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多肽球状脂联素通过抑制细胞凋亡和坏死性凋亡改善缺氧/复氧引起的心肌细胞损伤
DOI：
10.1155/2021/1815098
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发表时间：
2021
影响因子：
4.1
通讯作者：
Xiao C
中科院分区：
文献类型：
--
作者：
Zhu K;Guo J;Yu X;Wang Q;Yan C;Qiu Q;Tang W;Huang X;Mu H;Dou L;Bian Y;Han Q;Shen T;Li J;Xiao C
Adiponectin is a small peptide secreted and a key component of the endocrine system and immune system. Although globular adiponectin protects myocardial ischemia/reperfusion-induced cardiomyocyte injury, the protective mechanisms remain largely unresolved. Using a neonatal rat ventricular myocyte hypoxia/reoxygenation model, we investigated the role of its potential mechanisms of necroptosis in globular adiponectin-mediated protection in hypoxia/reoxygenation-induced cardiomyocyte injury as compared to apoptosis. We found that globular adiponectin treatment attenuated cardiomyocyte injury as indicated by increased cell viability and reduced lactate dehydrogenase release following hypoxia/reoxygenation. Immunofluorescence staining and Western blotting demonstrated that both necroptosis and apoptosis were triggered by hypoxia/reoxygenation and diminished by globular adiponectin. Necrostatin-1 (RIP1-specific inhibitor) and Z-VAD-FMK (pan-caspase inhibitor) only mimicked the inhibition of necroptosis and apoptosis, respectively, by globular adiponectin in hypoxia/reoxygenation-treated cardiomyocytes. Globular adiponectin attenuated reactive oxygen species production, oxidative damage, and p38MAPK and NF-κB signaling, all important for necroptosis and apoptosis. Collectively, our study suggests that globular adiponectin inhibits hypoxia/reoxygenation-induced necroptosis and apoptosis in cardiomyocytes probably by reducing oxidative stress and interrupting p38MAPK signaling.
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影响因子：
--
作者：
Cao Y;Shen T;Huang X;Lin Y;Chen B;Pang J;Li G;Wang Q;Zohrabian S;Duan C;Ruan Y;Man Y;Wang S;Li J
通讯作者：
Li J
影响因子：
4.6
作者：
Adameova, Adriana;Goncalvesova, Eva;Dhalla, Naranjan S.
通讯作者：
Dhalla, Naranjan S.
影响因子：
6.3
作者：
Northington, Frances J.;Chavez-Valdez, Raul;Martin, Lee J.
通讯作者：
Martin, Lee J.
影响因子：
4.8
作者：
Onay-Besikci, A;Altarejos, JY;Lopaschuk, GD
通讯作者：
Lopaschuk, GD
影响因子：
3.5
作者：
Kasof, GM;Prosser, JC;Gomes, BC
通讯作者：
Gomes, BC