Safety limit of large-volume hepatic radiofrequency ablation in a rat model
Safety limit of large-volume hepatic radiofrequency ablation in a rat model
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DOI：
10.1001/archsurg.141.3.252
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发表时间：
2006-03-01
影响因子：
--
通讯作者：
Fan, ST
中科院分区：
文献类型：
--
作者：
Ng, KK;Lam, CM;Fan, ST
背景：大容量肝脏射频消融（RFA）已被用于治疗大型肝脏肿瘤，但其安全限度尚不清楚。本研究旨在研究大体积肝脏RFA可能的全身反应，并估计其在正常和肝硬化大鼠中的安全限度。假设：大体积肝脏RFA导致显著的全身炎症反应。设计：实验研究。设置：大学教学医院。干预：使用Cool-tip射频系统（Radionics，Burlington，Mass），在正常和痴呆的Sprague-Dawley大鼠中，对不同重量百分比的肝脏体积进行RFA。评估血清炎症标志物（肿瘤坏死因子α [TNF-α]和白细胞介素[IL] 6）浓度、各种终末器官功能和存活率的变化。结果如下：在正常肝脏组中，TNF-α和IL-6的浓度在术后早期显著升高，（平均+/- SD TNF-α浓度，130.3 +/- 15.6 pg/mL;平均+/- SD IL-6浓度，163.2 +/- 12.2 pg/mL）和60%（平均+/- SD TNF-α浓度，145.7 +/- 13.0 pg/mL;与对照组（平均SD TNF-α浓度，30.4 +/- 9.9 pg/mL，P
Background: Large-volume hepatic radiofrequency ablation (RFA) has been used to treat large liver tumors, but its safety limit is unknown. This study aimed to investigate the possible systemic responses of largevolume hepatic RFA and to estimate its safety limit in normal and cirrhotic rats.Hypothesis: Large-volume hepatic RFA causes a significant systemic inflammatory reaction.Design: Experimental study.Setting: University teaching hospital.Intervention: Using the Cool-tip RF System (Radionics, Burlington, Mass), RFA was performed for different percentages of the liver volume by weight in normal and cirrhotic Sprague-Dawley rats.Main Outcome Measures: Changes in concentrations of serum inflammatory markers (tumor necrosis factor alpha [TNF-alpha] and interleukin [IL] 6), functions of various end organs, and survival rates were assessed. Results: In the normal liver groups, the concentrations of TNF-alpha and IL-6 were significantly elevated in the early postoperative period when 50% (mean +/- SD TNF-alpha concentration, 130.3 +/- 15.6 pg/mL; mean +/- SD IL-6 concentration, 163.2 +/- 12.2 pg/mL) and 60% (mean +/- SD TNF-alpha concentration, 145.7 +/- 13.0 pg/mL; mean SD IL-6 concentration, 180.8 +/- 11.0 pg/mL) of the liver volume were ablated compared with the control group (mean SD TNF-a concentration, 30.4 +/- 9.9 pg/mL, P