The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression
The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression
复制标题
犬血管肉瘤中组蛋白赖氨酸去甲基化酶2B的表达与疾病进展相关
DOI：
10.1111/vco.12796
复制
发表时间：
2021
影响因子：
2.1
通讯作者：
Kimura Takashi
中科院分区：
文献类型：
--
作者：
Gulay Kevin Christian M.;Aoshima Keisuke;Kim Sangho;Kitaguchi Ryusei;Kobayashi Atsushi;Kimura Takashi
犬血管肉瘤（HSA）是一种高度致命的间叶肿瘤，起源于血管内皮细胞。它的特点是生存时间短，平均生存时间仅为4个月。最近，我们发现组蛋白赖氨酸脱甲基酶2B（KDM2B）在犬HSA中高度表达，并通过积极调节DNA修复机制在HSA肿瘤细胞存活中起重要作用。据报道，KDM2B与几种人类癌症的疾病进展和患者生存有关。因此，在本研究中，我们研究了KDM2B表达水平与几种患者临床特征的关系，以研究KDM2B在临床HSA肿瘤中的作用。我们分析了37例犬HSA病例，发现KDM2B在3期HSA中的表达高于1期HSA。与雌性犬相比，在雄性犬中也发现了高KDM2B表达。KDM2B表达与年龄无相关性。将HSA患者分为高和低KDM2B表达组，发现高KDM2B组的总生存期比低KDM2B组短。基于这些结果，我们认为KDM2B表达与HSA的疾病进展相关。
Canine hemangiosarcoma (HSA), a highly fatal mesenchymal tumour of dogs, originates from the endothelial cells lining of blood vessels. It is characterized by a short survival time with a mean survival time of only 4 months. Recently, we showed that histone lysine demethylase 2B (KDM2B) was highly expressed in canine HSA and was important in HSA tumour cell survival by positively regulating DNA repair mechanisms. KDM2B has been reported to be related to disease progression and patient survival in several human cancers. Thus, in this study, we studied the relationship of KDM2B expression levels with several patient clinical profiles to investigate the role of KDM2B in clinical HSA tumours. We analysed 37 canine HSA cases and found that KDM2B is highly expressed in stage 3 HSA compared to stage 1 HSA. High KDM2B expression was also found in male dogs compared to female dogs. No correlation was observed between KDM2B expression and age. Classifying HSA patients into high and low KDM2B expression groups revealed that the high KDM2B group showed shorter overall survival than the low KDM2B group. Based on these results, we suggest that KDM2B expression is associated with disease progression in HSA.