Placenta as a newly identified source of hematopoietic stem cells.
Placenta as a newly identified source of hematopoietic stem cells.
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DOI：
10.1097/moh.0b013e328339f295
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发表时间：
2010-07
影响因子：
3.2
通讯作者：
Mikkola HK
中科院分区：
文献类型：
--
作者：
Lee LK;Ueno M;Van Handel B;Mikkola HK
The lifelong stream of all blood cells originates from the pool of hematopoietic stem cells (HSC) generated during embryogenesis. Given that the placenta has been recently unveiled as a major hematopoietic organ that supports HSC development, the purpose of this review is to present current advances in defining the origin and regulation of placental HSCs. The mouse placenta has been shown to have the potential to generate multipotential myelo-lymphoid hematopoietic stem/progenitor cells (HS/PC) de novo. The cellular origin of HSCs generated in the placenta and other sites has been tracked to the hemogenic endothelium by using novel genetic and imaging-based cell-tracing approaches. Transplantable, myelo-lymphoid HS/PCs have also been recovered from the human placenta throughout gestation. The discovery of the placenta as a major organ that generates HSCs and maintains them in an undifferentiated state provides a valuable model to further elucidate regulatory mechanisms governing HSC emergence and expansion during mouse and human development. Concurrent efforts to optimize protocols for placental banking and HSC harvesting may increase the therapeutic utility of the human placenta as a source of transplantable HSCs.
