A 5-year longitudinal study of association of maximum bite force with development of frailty in community-dwelling older adults
A 5-year longitudinal study of association of maximum bite force with development of frailty in community-dwelling older adults
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DOI：
10.1111/joor.12578
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发表时间：
2018-01-01
影响因子：
2.9
通讯作者：
Miyazaki, H.
中科院分区：
文献类型：
--
作者：
Iwasaki, M.;Yoshihara, A.;Miyazaki, H.
确定最大咬合力（MBF），口腔功能的客观指标，是否与社区居住的老年人虚弱的发展有关。这项前瞻性队列研究纳入了基线时年龄75岁的社区居住日本成年人（n = 322）。使用电子记录装置（咬合力计GM 10）测量基线MBF。在5年期间每年进行一次随访检查，包括身体健康和人体测量评价以及结构化问卷，以确定虚弱的发生率，虚弱的定义是存在来自心血管健康研究的以下5个组成部分中的3个或更多：低水平的移动性、低体力活动水平、虚弱、萎缩以及耐力和能量差。根据基线MBF的性别分层三分位数，使用考克斯比例风险回归模型计算虚弱发生率的校正风险比（HR）。在随访期间，49名参与者（15.2%）出现虚弱。MBF较低三分位数的参与者比较高三分位数的参与者表现出更大的虚弱风险。校正性别、抑郁、糖尿病和Eichner指数后，MBF上三分位数至下三分位数中虚弱的校正HR分别为1.00（参考）、1.27（95%置信区间[CI]：0.50 - 3.20）和2.78（95% CI：1.15 - 6.72）（趋势P = 0.01）。口腔功能差，如低MBF所示，增加了老年男性和女性发展虚弱的风险。
To determine whether maximum bite force (MBF), an objective measure of oral function, is associated with development of frailty in community-dwelling older adults. This prospective cohort study included community-dwelling Japanese adults aged 75years at baseline (n=322). Baseline MBF was measured using an electronic recording device (Occlusal Force-Meter GM10). Follow-up examinations, including physical fitness and anthropometric evaluation and structured questionnaires, were administered annually over a 5-year period to determine the incidence of frailty, which was defined by the presence of 3 or more of the following 5 components derived from the Cardiovascular Health Study: low level of mobility, low physical activity level, weakness, shrinking and poor endurance and energy. Adjusted hazard ratios (HRs) of incidence of frailty according to sex-stratified tertiles of baseline MBF were calculated using Cox proportional hazards regression models. During the follow-up, 49 participants (15.2%) developed frailty. Participants in the lower tertile of MBF exhibited a significantly greater risk of frailty than those in the upper tertile. After adjustment for sex, depression, diabetes and Eichner index, the adjusted HRs for frailty in the upper through lower tertiles of MBF were 1.00 (reference), 1.27 (95% confidence interval [CI]: 0.50-3.20) and 2.78 (95% CI: 1.15-6.72), respectively (P for trend=.01). Poor oral function, as indicated by low MBF, increases the risk of development of frailty among elderly men and women.