Central fat mass versus peripheral fat and lean mass: Opposite (adverse versus favorable) associations with arterial stiffness? The Amsterdam Growth and Health Longitudinal Study
Central fat mass versus peripheral fat and lean mass: Opposite (adverse versus favorable) associations with arterial stiffness? The Amsterdam Growth and Health Longitudinal Study
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DOI：
10.1210/jc.2003-031619
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发表时间：
2004-06-01
影响因子：
5.8
通讯作者：
Stehouwer, CDA
中科院分区：
文献类型：
--
作者：
Ferreira, I;Snijder, MB;Stehouwer, CDA
中枢性和外周性肥胖似乎对心血管风险具有相反的影响（即不利与保护），但其发生机制尚不清楚。此外，周围瘦肉团的作用也有待阐明。因此，我们对336名（175名女性）36岁且明显健康的成年人进行了调查，一方面是躯干脂肪、外周脂肪和外周瘦质量之间的关系，另一方面是对三条大动脉僵硬度的估计。采用双能x线吸收仪测定体成分。通过超声显像评估动脉特性。我们发现1)躯干脂肪与颈动脉和股动脉的僵硬度呈正相关（即负相关），而外周脂肪与肱动脉和颈动脉-股动脉段的僵硬度呈负相关（即有利）；2)外周瘦质量与动脉直径和颈动脉顺应性呈正相关，与颈-股节段刚度呈负相关；3)在调整其他身体组成变量后，上述关联仍然存在，但外周脂肪如果有的话，与股动脉僵硬度呈正相关。我们得出的结论是，躯干脂肪与大动脉僵硬度呈负相关，而外周脂肪和瘦质量则具有一定程度的保护作用。
Central and peripheral fatness seem to confer opposite (i.e. adverse vs. protective) effects on cardiovascular risk, but how this occurs is not clear. In addition, the role of peripheral lean mass needs to be elucidated. We therefore investigated, in 336 ( 175 women) 36-yr-old and apparently healthy adults, the relationship between trunk fat, peripheral fat, and peripheral lean mass on the one hand, and estimates of stiffness of three large arteries on the other. Body composition was assessed by dual-energy x-ray absorptiometry. Arterial properties were assessed by ultrasound imaging. We found that 1) trunk fat was positively (i.e. adversely) associated with stiffness of the carotid and femoral arteries, whereas peripheral fat was inversely e. favorably) associated with stiffness of the brachial and the carotido-femoral segment; 2) peripheral lean mass was positively associated with arterial diameter and carotid compliance and inversely associated with stiffness of the carotido-femoral segment; and 3) after adjustment for the other body composition variables, the above-mentioned associations remained, but peripheral fat in addition became, if anything, favorably associated with stiffness of the femoral artery. We conclude that trunk fat is adversely associated with large artery stiffness, whereas some degree of protection is conferred by peripheral fat and lean mass.