Human medial intraparietal cortex subserves visuomotor coordinate transformation
Human medial intraparietal cortex subserves visuomotor coordinate transformation
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DOI：
10.1016/j.neuroimage.2004.08.031
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发表时间：
2004-12-01
期刊：
影响因子：
5.7
通讯作者：
Fink, GR
中科院分区：
文献类型：
--
作者：
Grefkes, C;Ritzl, A;Fink, GR
在猕猴中，后顶叶皮层（PPC）整合多模态感觉信息，用于规划和协调复杂的运动。特别是，顶内沟（IPS）周围的区域作为感觉和运动系统之间的接口，以允许在空间中协调运动。由于最近的成像研究表明，人类和猴子IPS的功能和解剖组织相当，我们假设，在人类中，在猕猴，内侧顶内皮层（区MIP）subserves visualisation transformations。为了验证这一假设，使用功能性磁共振成像（fMRI）测量神经活动的变化，而健康受试者进行操纵杆范式类似于以前在猕猴研究区MIP。正如假设的那样，视觉坐标变换subserving目标导向的手部运动激活了上级顶叶皮层与局部最大的增加神经活动躺在内侧壁的IPS。相比各自的视觉控制条件下，目标导向的手运动下，主要是本体感受控制激活内侧IPS的更前部，而后内侧IPS更响应于视觉引导的手运动。对比两个坐标转换条件，改变运动指导的方式（视觉/本体感受）并没有显着改变IPS内的BOLD信号，但表现出差异招聘的方式特定的领域，如V5/MT和感觉运动皮层/区5，分别。这些数据表明，人类内侧顶内皮层subserves视觉转换过程，以控制目标为导向的手的动作独立于视觉或本体感受信息的模态特定的处理。(C)2004爱思唯尔公司All rights reserved.
In the macaque, the posterior parietal cortex (PPC) integrates multimodal sensory information for planning and coordinating complex movements. In particular, the areas around the intraparietal sulcus (IPS) serve as an interface between the sensory and motor systems to allow for coordinated movements in space. Because recent imaging studies suggest a comparable functional and anatomical organization of human and monkey IPS, we hypothesized that in humans, as in macaques, the medial intraparietal cortex (area MIP) subserves visuomotor transformations. To test this hypothesis, changes of neural activity were measured using functional magnetic resonance imaging (fMRI) while healthy subjects performed a joystick paradigm similar to the ones previously employed in macaques for studying area MIP. As hypothesized, visuomotor coordinate transformation subserving goal-directed hand movements activated superior parietal cortex with the local maximum of increased neural activity lying in the medial wall of IPS. Compared to the respective visuomotor control conditions, goal-directed hand movements under predominantly proprioceptive control activated a more anterior part of medial IPS, whereas posterior medial IPS was more responsive to visually guided hand movements. Contrasting the two coordinate transformation conditions, changing the modality of movement guidance (visual/proprioceptive) did not significantly alter the BOLD signal within IPS but demonstrated differential recruitment of modality specific areas such as V5/MT and sensorimotor cortex/area 5, respectively. The data suggest that the human medial intraparietal cortex subserves visuomotor transformation processes to control goal-directed hand movements independently from the modality-specific processing of visual or proprioceptive information. (C) 2004 Elsevier Inc. All rights reserved.