Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders
Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders
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DOI：
10.1038/s41562-019-0659-6
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发表时间：
2019-09-01
影响因子：
29.9
通讯作者：
van den Heuvel, Martijn P.
中科院分区：
文献类型：
--
作者：
de Lange, Siemon C.;Scholtens, Lianne H.;van den Heuvel, Martijn P.
宏观白质通路是人脑大规模通讯的基础设施，也是健康大脑功能的先决条件。大脑连接结构的破坏在许多精神和神经性脑部疾病中发挥着重要作用。在这里，我们表明，对于全球通信和网络整合很重要的连接特别容易受到多种大脑疾病的大脑改变的影响。我们报告了一项跨疾病连接组研究，共有 1,033 名患者和 1,154 名匹配对照者参与，涉及 8 种精神疾病和 4 种神经系统疾病。我们提取了这 12 种疾病中每一种的疾病连接组指纹，并将它们组合成一个“跨疾病断开连接参与图”，描述了人脑网络每个白质通路的跨疾病参与水平。网络分析揭示了全球网络通信和整合的核心连接，显示出跨疾病的高度干扰，表明普遍的跨疾病参与以及这些通路在正常功能中的重要性。
Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain's connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study comprising in total 1,033 patients and 1,154 matched controls across 8 psychiatric and 4 neurological disorders. We extracted disorder connectome fingerprints for each of these 12 disorders and combined them into a 'cross-disorder disconnectivity involvement map' describing the level of cross-disorder involvement of each white matter pathway of the human brain network. Network analysis revealed connections central to global network communication and integration to display high disturbance across disorders, suggesting a general cross-disorder involvement and the importance of these pathways in normal function.