Placental peptides metabolism and maternal factors as predictors of risk of gestational diabetes in pregnant women. A case-control study.
Placental peptides metabolism and maternal factors as predictors of risk of gestational diabetes in pregnant women. A case-control study.
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DOI：
10.1371/journal.pone.0181613
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Awe MA
中科院分区：
文献类型：
--
作者：
Ngala RA;Fondjo LA;Gmagna P;Ghartey FN;Awe MA
妊娠期糖尿病是围产期并发症的风险因素；包括肩部难产、出生损伤，如骨折和神经瘫痪。它与2型糖尿病的后期发展、巨大儿的风险以及糖尿病母亲所生婴儿的其他长期健康影响有关。这项研究评估了胎盘肽和母体因素作为孕妇妊娠期糖尿病的潜在预测因素。共招募了200名孕妇参加研究，其中150名非妊娠期糖尿病孕妇作为对照组，其中50名糖尿病低风险因素孕妇作为对照组，50名其他妊娠期糖尿病孕妇作为对照组。空腹血糖和血脂的测定采用酶促法，使用Entreme®500试剂(VITAL DIANSICS，美国)。糖化血红蛋白的测定采用阳离子交换树脂法。采用双抗体夹心法测定瘦素和人胎盘催乳素。在MAGLUMI600型生化分析仪上用化学发光免疫分析技术测定β绒毛膜促性腺激素、胰岛素、孕酮和雌二醇。人体测量，包括体重指数和血压也被测量。妊娠期糖尿病患者空腹血糖、胰岛素、胰岛素抵抗、糖化血红蛋白和人胎盘催乳素显著升高(p<；0.0001)，孕酮和雌二醇显著降低。然而，在妊娠中期，患有妊娠期糖尿病的孕妇和未患妊娠期糖尿病的孕妇在雌二醇、胰岛素、胰岛素抵抗和HPL方面没有显著差异(p>；0.05)。妊娠期糖尿病患者血清瘦素、孕酮、空腹血糖显著升高。超重(OR=1.76，P=0.370)和糖尿病家族史(OR=2.18，P=0.282)是妊娠期糖尿病的危险因素。本研究估计的瘦素、孕酮、雌二醇在妊娠期糖尿病妇女中升高，在非糖尿病孕妇中有较好的预测作用。肥胖、衰老和糖尿病家族史对妊娠期糖尿病有很强的预测作用。
Gestational diabetes is a risk factor for perinatal complications; include shoulder dystocia, birth injuries such as bone fractures and nerve palsies. It is associated with later development of type 2 diabetes, the risk of macrosomia and other long-term health effects of infants born to diabetic mothers. The study assesses placental peptides and maternal factors as potential predictors of gestational diabetes among pregnant women. A total of 200 pregnant women were recruited for the study, 150 pregnant women without pre gestational diabetes including 50 women with low risk factors of diabetes as controls and 50 other pregnant women with pregestational diabetes as control. Fasting blood glucose and the lipid profile were determined by enzymatic methods using Envoy® 500 reagents (Vital Diagnostics, USA). Glycated haemoglobin was assessed using the Cation Exchange resin method. Leptin and the Human Placenta Lactogen were assayed using the Sandwich-ELISA technique. Beta chorionic gonadotrophin, insulin, progesterone and estradiol were determined using chemilumiscence imunoassay technique on MAGLUMI 600 analyzer. Anthropometry, including BMI and blood pressure were also measured. Fasting plasma glucose (FBG), insulin, insulin resistance, glycated haemoglobin and Human Placenta Lactogen(HPL)were significantly (p<0.0001) increased in the pregestational diabetic women whereas progesterone and estradiol were significantly decreased. In the second trimester however, there was no significant difference (p>0.05) in estradiol, insulin, insulin resistance and HPL between the pregnant women who developed gestational diabetes and those who did not. Leptin, progesterone and FBG were significantly increased in those who developed GDM. The risk of developing gestational diabetes increased with overweight (OR = 1.76, P = 0.370) and family history of diabetes (OR = 2.18, P = 0.282). Leptin, progesterone, estradiol estimated in this study were increased in the gestational diabetes mellitus women and fairly predicted gestational diabetes in the non-diabetics pregnant women. Obesity, aging and family history of diabetes were strongly predictive of gestational diabetes.
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影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
8
作者：
Boney, CM;Verma, A;Vohr, BR
通讯作者：
Vohr, BR
DOI：
10.1016/0002-9378(93)90358-p
发表时间：
1993-04-01
影响因子：
9.8
作者：
COUSTAN, DR;CARPENTER, MW;CARR, SR
通讯作者：
CARR, SR
影响因子：
16.2
作者：
Lee, Anna J.;Hiscock, Richard J.;Permezel, Michael
通讯作者：
Permezel, Michael
影响因子：
16.2
作者：
Desoye, Gernot;Mouzon, Sylvie Hauguel-De
通讯作者：
Mouzon, Sylvie Hauguel-De