Suppression of systemic lupus erythematosus in NZBWF1 mice infected with Hymenolepis microstoma.
Suppression of systemic lupus erythematosus in NZBWF1 mice infected with Hymenolepis microstoma.
复制标题
抑制感染膜壳小孔的 NZBWF1 小鼠的系统性红斑狼疮。
DOI：
10.1016/j.parint.2020.102057
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
HISAEDA H.
中科院分区：
文献类型：
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作者：
OLIA A;SHIMOKAWA C;IMAI T;SUZUE K;HISAEDA H.
肠道蠕虫诱导免疫抑制反应，被认为是调节炎症性疾病，包括过敏和自身免疫性疾病。本研究旨在评估蠕虫感染是否抑制NZBWF 1小鼠系统性红斑狼疮（SLE）的自然发展。用两种线虫感染NZBWF1 SLE易感小鼠未能建立持久的定居点。然而，小口膜壳绦虫（Hm）啮齿动物绦虫成功地建立了NZBWF 1小鼠的长期寄生，并用于评估蠕虫感染的抑制作用。10个月大的NZBWF 1小鼠出现了包括自身抗体产生、蛋白尿、肾小球组织病理学和脾肿大在内的症状，但2个月大时感染Hm的小鼠没有表现出任何临床体征。此外，感染Hm减少淋巴细胞活化和增加调节性T细胞在脾脏和肠系膜淋巴结。这些结果表明，感染Hm保护NZBWF 1小鼠免受自然发展的SLE，并表明病理性免疫减弱，可能是因为调节性T细胞的诱导。
Intestinal helminths induce immune suppressive responses thought to regulate inflammatory diseases including allergies and autoimmune diseases. This study was designed to evaluate whether helminthic infections suppress the natural development of systemic lupus erythematosus (SLE) in NZBWF1 mice. Infection of NZBWF1 SLE-prone mice with two nematodes failed to establish long-lasting settlement. However, theHymenolepis microstoma(Hm) rodent tapeworm successfully established long-term parasitization of NZBWF1 mice and was used to evaluate the suppressive effects of helminth infection. Ten-month-old NZBWF1 mice developed symptoms including autoantibody generation, proteinuria, glomerular histopathology, and splenomegaly, but mice infected with Hm at 2 months of age did not show any clinical signs. Furthermore, infection with Hm reduced lymphocyte activation and increased regulatory T cells in the spleen and mesenteric lymph nodes. These results indicate that infection with Hm protects NZBWF1 mice from naturally developing SLE and suggest that pathological immunity is attenuated, presumably because of the induction of regulatory T cells.