The selection of the α,β heterodimeric T-cell receptor for antigen.
The selection of the α,β heterodimeric T-cell receptor for antigen.
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选择 α,β 异二聚体 T 细胞受体作为抗原。
DOI:
10.1016/0167-5699(86)90139-8
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发表时间:
1986
期刊:
影响因子:
--
通讯作者:
H. Boehmer
中科院分区:
文献类型:
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作者:
H. Boehmer
T cells express α, β heterodimeric receptor proteins which are involved in the MHC-restricted binding of antigen (1, 2). The nucleotide sequences of T-cell receptor genes (3-6) have not provided an obvious explanation for the'MHC-ness' of T-cell specificity or the different specificity of T-cell subsets. The binding of α, β heterodimeric T-cell receptors has not yet been studied in solution so it is possible that T cells express additional molecules that are involved in antigen binding. Recent experimental data (7), reviewed in our last issue (Immunol. Today 1986, 7, 308-311) indicate that the α, β heterodimer alone is responsible for the MHC-restricted specificity of T cells. Here, Harald von Boehmer discusses the implications of these data and presents a model for the selection of α, β heterodimeric T-cell receptors during T-cell differentiation in the thymus.
DOI:
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发表时间:
1985
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Staerz,UD;Rammensee,HG;Benedetto,JD;Bevan,MJ
通讯作者:
Bevan,MJ
DOI:
--
发表时间:
1983
期刊:
Thymus
影响因子:
--
作者:
Scollay,R;Shortman,K
通讯作者:
Shortman,K