The selection of the α,β heterodimeric T-cell receptor for antigen.

The selection of the α,β heterodimeric T-cell receptor for antigen.
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选择 α,β 异二聚体 T 细胞受体作为抗原。

DOI:
10.1016/0167-5699(86)90139-8
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发表时间:
1986
期刊:
Immunology today
影响因子:
--
通讯作者:
H. Boehmer
H. Boehmer
中科院分区:
--
文献类型:
--
作者:
H. Boehmer

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T细胞表达参与抗原的MHC限制性结合的α,β异二聚体受体蛋白(1,2)。T细胞受体基因的核苷酸序列(3-6)没有为T细胞特异性的“MHC性”或T细胞亚群的不同特异性提供明显的解释。尚未在溶液中研究α,β异二聚体T细胞受体的结合,因此T细胞可能表达参与抗原结合的其他分子。最近的实验数据(7),在我们的上一期(Immunol. Today 1986,7,308-311)中综述,表明α,β异二聚体单独负责T细胞的MHC限制性特异性。在这里,Harald von Boehmer讨论了这些数据的含义,并提出了一个在胸腺T细胞分化期间选择α,β异二聚体T细胞受体的模型。
T cells express α, β heterodimeric receptor proteins which are involved in the MHC-restricted binding of antigen (1, 2). The nucleotide sequences of T-cell receptor genes (3-6) have not provided an obvious explanation for the'MHC-ness' of T-cell specificity or the different specificity of T-cell subsets. The binding of α, β heterodimeric T-cell receptors has not yet been studied in solution so it is possible that T cells express additional molecules that are involved in antigen binding. Recent experimental data (7), reviewed in our last issue (Immunol. Today 1986, 7, 308-311) indicate that the α, β heterodimer alone is responsible for the MHC-restricted specificity of T cells. Here, Harald von Boehmer discusses the implications of these data and presents a model for the selection of α, β heterodimeric T-cell receptors during T-cell differentiation in the thymus.
T 细胞抗原受体同种异型决定簇特异性鼠单克隆抗体的表征。
DOI: --
发表时间: 1985
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Staerz,UD;Rammensee,HG;Benedetto,JD;Bevan,MJ
通讯作者: Bevan,MJ
胸腺细胞亚群:实验综述,包括主要小鼠胸腺细胞标记物之间的流式细胞术互相关性。
DOI: --
发表时间: 1983
期刊: Thymus
影响因子: --
作者:
Scollay,R;Shortman,K
通讯作者: Shortman,K