Iron-catalysed alkene hydrogenation and reductive cross-coupling using a bench-stable iron(II) pre-catalyst
Iron-catalysed alkene hydrogenation and reductive cross-coupling using a bench-stable iron(II) pre-catalyst
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DOI：
10.1039/c3ra44519d
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发表时间：
2013-01-01
期刊：
影响因子：
3.9
通讯作者：
Thomas, Stephen P.
中科院分区：
文献类型：
--
作者：
Frank, Dominik J.;Guiet, Lea;Thomas, Stephen P.
操作简单，铁催化氢化和还原性交叉偶联协议已开发使用工作台稳定的铁（II）预催化剂。报道了18种烯烃的氢化（50-99%）和乙烯基卤化物与芳基和烷基格氏试剂的还原性交叉偶联（8个实施例，18-99%），使用3mol%的预催化剂和氢气作为化学计量还原剂（1-50巴）。
Operationally simple, iron-catalysed hydrogenation and reductive cross-coupling protocols have been developed using a bench-stable iron(II) pre-catalyst. The hydrogenation of 18 alkenes (50-99%) and reductive cross-coupling of vinyl halides with aryl- and alkyl Grignard reagents (8 examples, 18-99%) is reported using 3 mol% pre-catalyst and hydrogen as stoichiometric reductant (1-50 bar).