Leisure activities and the risk of dementia in the elderly Results from the Three-City Study
Leisure activities and the risk of dementia in the elderly Results from the Three-City Study
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DOI：
10.1212/wnl.0b013e3181b7849b
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发表时间：
2009-09-15
期刊：
影响因子：
9.9
通讯作者：
Berr, C.
中科院分区：
文献类型：
--
作者：
Akbaraly, T. N.;Portet, F.;Berr, C.
目的：越来越多的证据表明，参与休闲活动可能与痴呆症的风险有关;然而，关于这种关联的潜在机制还没有达成共识。假设休闲活动可能有助于认知储备（CR），我们研究了休闲活动与一般人群样本中痴呆及其亚型的发病风险之间的关系，将休闲活动分为刺激性、被动性、身体性和社交性。这些协会的可能性，可能是由其他代理的CR也examined.Methods：进行了分析，包括在三个城市的队列研究在第戎和蒙彼利埃（法国）在1999-2001年的5,698名无痴呆症的参与者年龄在65岁及以上。计算痴呆及其亚型的风险比（HR结果：刺激性休闲活动与痴呆风险降低显著相关（n = 161，HR = 0.49，95%置信区间[CI]：0.31; 0.79）和阿尔茨海默病（n = 105，HR = 0.39，95% CI：0.21; 0.71）在4年随访期间，1）独立于CR的其他代理，2）在调整血管风险因素、抑郁症状和身体功能后，（3）独立于其他休闲活动。此外，没有显着的关联被发现与其他休闲活动和痴呆症控制后的潜在confronters.Conclusion：我们的研究结果支持这一假设，即认知刺激休闲活动可能会延迟痴呆症的发病在社区居住的老人。神经病学（R）2009; 73：854-861
Objective: There is accumulating evidence that involvement in leisure activities may be related to risk of dementia; however, there is no consensus concerning the underlying mechanism of this association. Hypothesizing that leisure activities may contribute to cognitive reserve (CR), we examined the association between leisure activities and risk of incident dementia and its subtypes within a general population sample, categorizing leisure activity as stimulating, passive, physical, and social. The possibility that these associations may be driven by other proxies of CR was also examined.Methods: Analyses were carried out on 5,698 dementia-free participants aged 65 and over included in the Three-City cohort study in Dijon and Montpellier (France) in 1999-2001. Hazard ratios (HR) were calculated for incident dementia and its subtypes (mixed/vascular dementia and Alzheimer disease) in relation to category of leisure activity.Results: Stimulating leisure activities were found to be significantly associated with a reduced risk of dementia (n = 161, HR = 0.49, 95% confidence interval [CI]: 0.31; 0.79) and Alzheimer disease (n = 105, HR = 0.39, 95% CI: 0.21; 0.71) over the 4-year follow-up 1) independently of other proxies of CR, 2) after adjusting for vascular risk factors, depressive symptoms, and physical functioning, and 3) independently of other leisure activities. Furthermore, no significant association was found with other leisure activities and dementia after controlling for the potential confounders.Conclusion: Our findings support the hypothesis that cognitively stimulating leisure activities may delay the onset of dementia in community-dwelling elders. Neurology (R) 2009; 73: 854-861