An enduring role for quiescent stem cells.
An enduring role for quiescent stem cells.
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DOI：
10.1002/dvdy.24416
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
Breault DT
中科院分区：
文献类型：
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作者：
Richmond CA;Shah MS;Carlone DL;Breault DT
肠道从灾难性损伤中恢复的能力需要静止的肠道干细胞（q-ISCs）。虽然快速循环（Lgr 5+）隐窝基底柱状（CBC）ISC通常维持肠，但它们对病理损伤（辐射、炎症）高度敏感，并且必须由q-ISC恢复以维持肠内稳态。尽管与人类健康有明确的相关性，但实际上对调节q-ISCs的因素一无所知。对这些机制的全面理解可能会导致有针对性的新疗法，对胃肠道疾病患者具有深远的治疗意义。我们简要回顾了目前的文献状态，强调稳态机制的重要q-ISC的监管上市领域的关键问题，并提供策略来解决这些问题。
The intestine’s ability to recover from catastrophic injury requires quiescent intestinal stem cells (q-ISCs). While rapidly cycling (Lgr5+) crypt base columnar (CBC) ISCs normally maintain the intestine, they are highly sensitive to pathological injuries (irradiation, inflammation) and must be restored by q-ISCs in order to sustain intestinal homeostasis. Despite clear relevance to human health, virtually nothing is known regarding the factors that regulate q-ISCs. A comprehensive understanding of these mechanisms would likely lead to targeted new therapies with profound therapeutic implications for patients with gastrointestinal conditions. We briefly review the current state of the literature highlighting homeostatic mechanisms important for q-ISC regulation listing key questions in the field and offer strategies to address them.