Comparison of the Efficacy between Conventional Moxibustion and Smoke-Free Moxibustion on Knee Osteoarthritis: A Randomized Controlled Trial
Comparison of the Efficacy between Conventional Moxibustion and Smoke-Free Moxibustion on Knee Osteoarthritis: A Randomized Controlled Trial
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常规艾灸与无烟艾灸治疗膝骨关节炎的疗效比较：随机对照试验
DOI：
10.1155/2019/1291947
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Yu, Shu-guang
中科院分区：
文献类型：
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作者：
Luo, Ling;Liao, Mo;Yu, Shu-guang
目的探讨常规艾灸（CM）与无烟艾灸（SM）治疗膝关节骨性关节炎（KOA）的疗效差异。方法采用多中心、随机、单盲、平行组临床试验。将全国7家医院的KOA患者随机分为CM组（69例）和SM组（69例）。在3个穴位（EX-LE4、ST35、ST36）进行艾灸治疗，共12次，疗程4周。患者在基线和2周、4周、8周和12周后完成标准问卷。主要终点是西安大略省和麦克马斯特大学从基线到4周的骨关节炎指数（WOMAC）。次要结局包括视觉模拟评分（VAS）和患者整体评估评分（PGA）。结果分析显示，与4周时两组比较，WOMAC评分在疼痛（95% CI,-0.1[-1.2 ~ 0.9], p=0.76）、僵硬（95% CI,-0.1[-0.5 ~ 0.3], p=0.71）和功能（95% CI, 2.2 [-1.3 ~ 5.8], p=0.22）以及VAS评分（95% CI,0.1 [-0.3 ~ 0.6], p=0.60）方面均有改善。8周和12周时出现类似结果。CM组和SM组在结果测量方面无统计学差异。结论艾灸治疗过程中产生的烟雾不影响艾灸治疗KOA的疗效，为减少针灸师或患者对环境的污染或艾灸烟雾暴露，应予以考虑并予以消除。该试验已在Clinical Trials.gov注册，编号NCT02772055。
Objective The aim of this study was to investigate the difference of efficacy between conventional moxibustion (CM) and smoke-free moxibustion (SM) for patients with osteoarthritis of the knee (KOA). Methods This is a multicentre, randomized, single blinded, parallel-group clinical trial. Patients with KOA were randomly allocated to CM group (69) and SM group (69) in 7 hospitals of China. Moxibustion treatment in 12 sessions over 4 weeks was administrated at 3 acupuncture points (EX-LE4, ST35, and ST36). Patients completed standard questionnaires at baseline and after 2 weeks, 4 weeks, 8 weeks, and 12 weeks. The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) from the baseline to 4 weeks. The secondary outcomes include Visual Analogue Scale (VAS) and Patient Global Assessment score (PGA). Results Analyses showed that the WOMAC score improved in pain (95% CI,-0.1[-1.2 to 0.9], p=0.76), stiffness (95% CI,-0.1 [-0.5 to 0.3], p=0.71), and function (95% CI, 2.2 [-1.3 to 5.8], p=0.22) compared between the two groups at 4 weeks, as well as the VAS score (95% CI,0.1 [-0.3 to 0.6], p=0.60). Similar results presented at 8 and 12 weeks. No statistically significant difference was observed between CM and SM groups for outcome measurements. Conclusions It suggested that smoke generated during moxibustion treatment does not affect the efficacy of moxibustion in the treatment of KOA, which should be taken into account to be removed for the sake of reducing environmental pollution or moxa smoke exposure of acupuncturists or patients. This trial is registered with Clinical Trials.gov, NCT02772055.