PERCEPTUAL CONSEQUENCES OF ELECTRICAL-STIMULATION IN THE GUSTATORY SYSTEM
PERCEPTUAL CONSEQUENCES OF ELECTRICAL-STIMULATION IN THE GUSTATORY SYSTEM
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DOI：
10.1037/0735-7044.107.1.130
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发表时间：
1993-02-01
影响因子：
1.9
通讯作者：
HECHT, GS
中科院分区：
文献类型：
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作者：
DILORENZO, PM;HECHT, GS
为了研究时间编码在味觉神经加工中的作用，将不同频率的电脉冲串传递到清醒大鼠的孤束核(NTS)。这些序列的时间模式模仿了单个神经元对自然味道的电生理反应的时间模式。在实验1中，缺水大鼠首先被训练在实验舱里舔水。在训练日，舔水会在NTS产生类似蔗糖的电脉冲序列。在这些疗程结束时，实验动物被注射氯化锂致病，随后当氯化锂与NTS刺激配对时，它们学会了避免舔。在实验2中，大鼠在舔水时拒绝舔水，产生了类似奎宁的NTS刺激模式，但当舔产生类似于对蔗糖的自然反应的NTS刺激模式时，老鼠热情地舔着。
To investigate the role of temporal coding in the neural processing of taste, trains of electrical pulses of varying frequency were delivered to the nucleus of the solitary tract (NTS) in awake rats. The temporal patterns of these trains mimicked the temporal patterns of electrophysiological responses of single neurons to natural tastes. In Experiment 1, water-deprived rats were first trained to lick water in an experimental chamber. On training days, licking water produced a sucroselike electrical pulse train in the NTS. At the end of these sessions, experimental animals were made ill by an injection of LiCl and subsequently learned to avoid licking when LiCl was paired with NTS stimulation. In Experiment 2, rats refused to lick water when licking produced a quininelike pattern of NTS stimulation but licked enthusiastically when licking produced a pattern of NTS stimulation similar to the natural response to sucrose.