Compensating for alcohol-induced impairment: Alcohol expectancies and behavioral disinhibition
Compensating for alcohol-induced impairment: Alcohol expectancies and behavioral disinhibition
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DOI：
10.15288/jsa.2002.63.237
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发表时间：
2002-03-01
期刊：
影响因子：
--
通讯作者：
Blackburn, J
中科院分区：
文献类型：
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作者：
Fillmore, MT;Blackburn, J
目的：研究表明，酒精损伤的期望可以产生适应性反应，使血清c降低酒精对行为损伤的程度。本研究探讨了期望诱导的适应性反应如何降低酒精对反应激活的损伤作用。而同时增加其对反应抑制的削弱作用。方法：社交饮酒者（N = 48）进行了停止信号选择反应时间（RT）任务，测量他们的反应速度和抑制反应的能力，停止信号。然后，受试者接受0.65 g/kg的酒精、安慰剂饮料或不接受饮料。在再次执行任务之前，将一半的样品作为预期酒精会减慢的给定信息（即，结果：与未接受预期治疗的受试者相比，预期RT减慢的受试者在酒精下的RT加快，但抑制减少。结果模式与安慰剂条件下观察到的结果模式相同。在“无饮料”的条件下，预期治疗对受试者的RT或抑制没有显着影响，结论：研究结果表明，酒精预期可以减少药物骡子增加它，损害另一个方面的性能的损害。这些研究成果为越来越多的研究做出了贡献，这些研究强调了理解酒精的预期作用和药理作用之间相互作用的重要性。
Objective: Studies have shown that expectations of alcohol-induced impairment can produce adaptive responses to alcohol that sera c to reduce the degree of behavioral impairment displayed, The present research examined how an expectancy-induced adaptive response could reduce the impairing effects of alcohol on response activation. while at the same time increase its impairing effect on response inhibition. Method: Social drinkers (N = 48) practiced a stop-signal choice reaction time (RT) task that measured their speed of responding and their ability to inhibit response,, to stop signals. Subjects then received 0,65 g kg of alcohol, a placebo beverage, or no beverage, Prior to performing the task again, one-half of the sample as given information to expect that alcohol would slow (i.e., impair) their RT. The others received no expectancy treatment, Results: Subjects led to expect slowed RT displayed faster RTs but fewer inhibitions under alcohol, compared with those who received no such expectancy. The same pattern of results as observed under the placebo condition. In the "no beverage" condition, the expectancy treatment had no significant effect on subjects' RT or inhibitions, Conclusions: The findings demonstrate that an alcohol expectancy can reduce impairment of one aspect of performance under the drug Mule increasing it, impairing effect on another. The studs contributes to a growing body of research that highlights the importance of understanding interactions between the expected and pharmacological effects of alcohol.