Ventricular dysfunction and dilation in severe sepsis and septic shock: Relation to endothelial function and mortality
Ventricular dysfunction and dilation in severe sepsis and septic shock: Relation to endothelial function and mortality
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DOI：
10.1016/j.jcrc.2011.06.017
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发表时间：
2012-06-01
影响因子：
3.7
通讯作者：
Biolo, Andreia
中科院分区：
文献类型：
--
作者：
Furian, Thiago;Aguiar, Cyntia;Biolo, Andreia
目的：本研究的目的是评价严重脓毒症早期基于超声心动图的心肌功能指标以及血管炎症和内皮功能障碍标志物。材料和方法：研究45例成年患者（67%为女性，年龄51 +/- 18岁，急性生理学和慢性健康疾病分类系统II评分，23 +/- 7）在满足严重脓毒症或感染性休克标准后24小时内入住重症监护病房。入院后24小时、72小时和7天分别收集临床、实验室（内皮素1 [ET1]、血管细胞粘附分子1）和超声心动图数据。结果：院内死亡率为33%（死亡15例）。左心室功能障碍（左室射血分数）
Purpose: The aim of this study was to evaluate echocardiography-based indices of myocardial function and markers of vascular inflammation and endothelial dysfunction in the early phases of severe sepsis.Material and Methods: Forty-five adult patients (67% women; age 51 +/- 18 years; Acute Physiology and Chronic Health Disease Classification System II score, 23 +/- 7) admitted to the intensive care unit up to 24 hours after fulfilling criteria for severe sepsis or septic shock were studied. Clinical, laboratorial (endothelin 1 [ET1], vascular cellular adhesion molecule 1), and echocardiographic data were collected within the first 24 hours and again 72 hours and 7 days after admission.Results: Intrahospital mortality was 33% (15 deaths). Left ventricular (LV) dysfunction (LV ejection fraction