Neuronal correlates of depression.
Neuronal correlates of depression.
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DOI：
10.1007/s00018-015-2044-6
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Han MH
中科院分区：
文献类型：
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作者：
Chaudhury D;Liu H;Han MH
重度抑郁症（MDD）是一种常见的精神疾病，影响全世界约1.21亿人，世界卫生组织（WHO）最近的报告表明，它将成为全球疾病负担的主要贡献者。目前，最常用的治疗策略仍然是基于单胺假说，在过去的60年里，单胺假说一直是主导理论。临床观察表明，只有一个子集的抑郁症患者表现出完全缓解时，与经典的单胺为基础的抗抑郁药治疗的事实，患者表现出多种症状表明，导致情绪障碍的病理生理可能不同的患者。越来越多的证据表明，抑郁症是一种神经回路障碍，抑郁症的发病可能位于大脑的不同区域，涉及不同的递质系统和分子机制。本文综述了啮齿动物研究的结果，从不同的，但相互关联的，分子系统和相关的神经回路抑郁症的病因出现的作用。
Major depressive disorder (MDD) is a common psychiatric disorder effecting approximately 121 million people worldwide and recent reports from the World Health Organization (WHO) suggest that it will be the leading contributor to the global burden of diseases. At present the most commonly used treatment strategies are still based on the monoamine hypothesis that has been the predominant theory in the last 60 years. Clinical observations that only a subset of depressed patients exhibits full remission when treated with classical monoamine-based antidepressants together with the fact that patients exhibit multiple symptoms suggest that the pathophysiology leading to mood disorders may differ between patients. Accumulating evidence indicates that depression is a neural circuit disorder and that onset of depression may be located at different regions of the brain involving different transmitter systems and molecular mechanisms. This review synthesizes findings from rodent studies from which emerges a role for different, yet interconnected, molecular systems and associated neural circuits to the etiology of depression.