Smaller CpG-Conjugated Gold Nanoconstructs Achieve Higher Targeting Specificity of Immune Activation.
Smaller CpG-Conjugated Gold Nanoconstructs Achieve Higher Targeting Specificity of Immune Activation.
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DOI：
10.1021/acsami.8b06633
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发表时间：
2018-07-05
影响因子：
9.5
通讯作者：
Odom TW
中科院分区：
文献类型：
--
作者：
Yue J;Pallares RM;Cole LE;Coughlin EE;Mirkin CA;Lee A;Odom TW
This paper describes a side-by-side comparison of the in vitro immunostimulatory activity of CpG-conjugated gold nanoparticles. Three different gold nanoparticle cores (13-nm spheres, 50-nm spheres, and 40-nm stars) with the same CpG surface density were investigated for toll-like receptor 9 activation. For this parameter set, 13-nm spheres displayed significantly higher specificity for targeting immune receptors and larger nanoparticles (50-nm spheres and 40-nm stars) showed higher cellular uptake and higher immune activation because of off-target effects. Changes in nanoparticle size and presentation of activating ligands affect construct-induced immune responses at different levels, and care must be taken when considering practical and global design rules for CpG delivery.
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