Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure
Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure
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DOI：
10.1271/bbb.70498
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发表时间：
2007-12-01
影响因子：
1.6
通讯作者：
Nishimori, Katsuhiko
中科院分区：
文献类型：
--
作者：
Kasahara, Yoshiyuki;Takayanagi, Yuki;Nishimori, Katsuhiko
我们分析了催产素缺乏(oxt(-/-))小鼠的温度动态平衡，发现当oxt(-/-)小鼠暴露在寒冷中时，它们的体温低于野生型动物。OXT(-/-)小鼠的体重也略有增加，但白色和棕色脂肪组织的形态与野生型和OXT(-/-)小鼠之间没有明显差异。在冷暴露条件下，下丘脑室旁核内存在含有c-Fos免疫反应的催产素神经元，提示中枢催产素神经元是冷环境下维持体温的体温调节系统的一部分。
We analyzed temperature homeostasis in oxytocin-deficient (Oxt(-/-)) mice and found that Oxt(-/-) mice exhibited lower body temperatures than wild-type animals when they were exposed to cold. Oxt(-/-) mice also showed slightly more weight gain, but there were no obvious differences in the morphology of white and brown adipose tissues as between wild-type and Oxt(-/-) mice. In cold-exposed conditions, oxytocin neurons containing c-Fos immunoreactivity existed in the para-ventricular nucleus of the hypothalamus.These results suggest that the central oxytocin neurons constitute part of the thermoregulatory system involved in maintaining body temperature in cold environments.