Accessory protein regulation of microtubule dynamics throughout the cell cycle
Accessory protein regulation of microtubule dynamics throughout the cell cycle
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DOI：
10.1016/s0955-0674(99)80017-9
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发表时间：
1999-02-01
影响因子：
7.5
通讯作者：
Cassimeris, L
中科院分区：
文献类型：
--
作者：
Cassimeris, L
在分裂细胞中，一些辅助蛋白能够稳定或破坏微管聚合物。许多这些辅助蛋白被细胞周期依赖性磷酸化修饰和调节。通过这种调节，微管动力学被修改以在有丝分裂期间产生快速的微管周转。一般来说，尽管一些微管稳定蛋白在进入有丝分裂时失活，但微管稳定剂和不稳定剂之间的关键平衡对于有丝分裂纺锤体的组装是必要的。
A number of accessory proteins capable of stabilizing or destabilizing microtubule polymers in dividing cells have been identified recently. Many of these accessory proteins are modified and regulated by cell-cycle-dependent phosphorylation. Through this regulation, microtubule dynamics are modified to generate rapid microtubule turnover during mitosis. In general, although some microtubule-stabilizing proteins are inactivated at entry into mitosis, a critical balance between microtubule stabilizers and destabilizers is necessary for assembly of the mitotic spindle.