Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999-2002.
Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999-2002.
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DOI：
10.1097/ede.0000000000000299
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Epel ES
中科院分区：
文献类型：
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作者：
Needham BL;Rehkopf D;Adler N;Gregorich S;Lin J;Blackburn EH;Epel ES
这项研究在50-84岁的美国成年人中调查了白细胞端粒长度（细胞衰老的标志）与死亡率之间的关系。我们还研究了年龄、性别、种族/民族和教育的调节作用。数据来自1999-2002年全国健康和营养检查调查（NHANES） （n=3,091）。Cox比例风险回归用于估计全因和特定原因死亡率的风险，调整了社会人口统计学特征、吸烟、体重指数和慢性病。在平均9.5年的随访期间，有870人死亡。在整个样本中，端粒长度在基线时减少1千碱基对与全因死亡率增加10% （HR: 1.1, 95% CI: 0.9, 1.4）和因心血管疾病或癌症以外的疾病导致的死亡风险增加30% （HR: 1.3, 95% CI: 0.9, 1.9）轻微相关。在非裔美国人而非白人或墨西哥裔美国人的应答者中，端粒长度在基线时减少1000碱基对与心血管死亡风险增加两倍相关（HR: 2.0, 95% CI: 1.3, 3.1）。端粒长度和癌症死亡率之间没有关联。白细胞端粒长度与死亡率之间的关系因种族/民族和死亡原因而异。
This study examined the association between leukocyte telomere length – a marker of cell aging – and mortality in a nationally representative sample of US adults aged 50–84. We also examined moderating effects of age, sex, race/ethnicity, and education. Data were from the National Health and Nutrition Examination Survey (NHANES), 1999–2002 (n=3,091). Cox proportional hazards regression was used to estimate the risk of all-cause and cause-specific mortality adjusting for sociodemographic characteristics, smoking, body mass index, and chronic conditions. 870 deaths occurred over an average of 9.5 years of follow-up. In the full sample, a decrease of 1 kilobase pair in telomere length at baseline was marginally associated with a 10% increased hazard of all-cause mortality (HR: 1.1, 95% CI: 0.9, 1.4) and a 30% increased hazard of death due to diseases other than cardiovascular disease or cancer (HR: 1.3, 95% CI: 0.9, 1.9). Among African-American but not white or Mexican-American respondents, a decrease of 1 kilobase pair in telomere length at baseline was associated with a two-fold increased hazard of cardiovascular mortality (HR: 2.0, 95% CI: 1.3, 3.1). There was no association between telomere length and cancer mortality. The association between leukocyte telomere length and mortality differs by race/ethnicity and cause of death.