CO-LOCALIZATION OF MOLECULES INVOLVED IN ANTIGEN PROCESSING AND PRESENTATION IN AN EARLY ENDOCYTIC COMPARTMENT
CO-LOCALIZATION OF MOLECULES INVOLVED IN ANTIGEN PROCESSING AND PRESENTATION IN AN EARLY ENDOCYTIC COMPARTMENT
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DOI：
10.1038/343133a0
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发表时间：
1990-01-11
期刊：
影响因子：
64.8
通讯作者：
BRODSKY, FM
中科院分区：
文献类型：
--
作者：
GUAGLIARDI, LE;KOPPELMAN, B;BRODSKY, FM
参与抗原加工和呈递的细胞内运输途径已通过免疫电镜确定。II类组织相容性分子的输出途径和抗原输入途径在外周内吞隔室中相遇，该外周内吞隔室具有被认为是抗原加工和呈递所需的所有分子机制，包括内化的表面免疫球蛋白、蛋白水解酶和不变链。该隔室限定了一个位点，其中来自内吞抗原的肽可以在通往细胞表面以呈递给T细胞的途中结合II类分子。
The pathways of intracellular traffic involved in antigen processing and presentation have been defined by immunoelectron microscopy. The export pathway for class II histocompatibility molecules and the antigen import pathway meet in a peripheral endocytic compartment having all the molecular machinery believed to be required for antigen processing and presentation, including internalized surface immunoglobulins, proteolytic enzymes and invariant chains. This compartment defines a site where peptides from endocytosed antigen can bind class II molecules en route to the cell surface for presentation to T cells.