Role of prolactin in B cell regulation in multiple sclerosis
Role of prolactin in B cell regulation in multiple sclerosis
复制标题
DOI：
10.1016/j.jneuroim.2014.02.007
复制
发表时间：
2014-04-15
影响因子：
3.3
通讯作者：
Celica Ysrraelit, Maria
中科院分区：
文献类型：
--
作者：
Correale, Jorge;Farez, Mauricio F.;Celica Ysrraelit, Maria
探讨催乳素在多发性硬化症发病中的作用。与对照组相比，MS患者在缓解期和加重期的催乳素水平均较高。催乳素增加B细胞JAK2表达和Stat磷酸化，上调抗mog抗体分泌细胞数量、BAFF水平和bcl -2表达，下调Trp63表达。催乳素水平与抗mog分泌细胞数量呈正相关，与诱导的B细胞凋亡呈负相关。此外，催乳素降低B细胞受体介导的激活阈值，诱导B细胞中CD40的表达。这些发现表明催乳素通过不同的机制促进MS中B细胞的自身反应性。(C) 2014 Elsevier B.V.版权所有
The role of prolactin in MS pathogenesis was investigated. Prolactin levels were higher in MS subjects both during remission and exacerbation compared to control subjects. Prolactin increased JAK2 expression and Stat phosphorylation on B cells, up-regulated anti-MOG antibody secreting cell numbers, BAFF levels, and Bcl-2expression, and down-regulated expression of Trp63. Prolactin levels correlated positively with anti-MOG secreting cell numbers, and negatively with induced apoptotic B cells. Additionally, prolactin decreased B cell receptor-mediated activation threshold, and induced CD40 expression in B cells. These findings suggest that prolactin promotes B cell autoreactivity in MS through different mechanisms. (C) 2014 Elsevier B.V. All rights reserved.