Cartilage Intermediate Layer Protein Gene Is Associated With Lumbar Disc Degeneration in Male, but Not Female, Collegiate Athletes
Cartilage Intermediate Layer Protein Gene Is Associated With Lumbar Disc Degeneration in Male, but Not Female, Collegiate Athletes
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DOI：
10.1177/0363546510376714
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发表时间：
2010-12-01
影响因子：
4.8
通讯作者：
Hiranuma, Kenji
中科院分区：
文献类型：
--
作者：
Min, Seok-Ki;Nakazato, Koichi;Hiranuma, Kenji
背景资料：作者先前在大学男性柔道运动员中发现了腰椎间盘退变（LDDG）和软骨中间层蛋白（CILP）单核苷酸多态性（SNP）之间的显著关联。假设：在日本大学运动员中观察到LDDG和CILP SNP之间的显著关联。研究设计：横断面研究;证据等级，3.方法：参与者是来自7个不同运动项目的601名训练有素的大学运动员（男性，403人;女性，198人）。采用T2加权磁共振成像评价腰椎间盘退变。结果：在601名大学生运动员中，CILP C等位基因与LDDG发生的比值比（OR）为1.4（95%CI为1.05-1.86）。通过使用逻辑回归分析，伴随着交互作用项和Wald检验，作者发现，体重CILP基因型（OR，1.04; 95%CI，1.02-1.06）（CT：OR，2.0; 95% CI，1.24-3.15; CC：OR，2.9; 95% CI，1.09-7.74）和性别（OR，2.1; 95% CI，1.21-3.67）是LDDG的显著危险因素。结论：CILP基因1184 T/C多态性是影响大学生男运动员LDDG的危险因素。关于CILP基因多态性的信息可能对预防和管理腰椎间盘疾病很重要，特别是在男性运动员中。
Background: The authors previously identified a significant association between lumbar disc degeneration (LDDG) and cartilage intermediate layer protein (CILP) single nucleotide polymorphism (SNP) in collegiate male judokas.Hypothesis: A significant association between LDDG and the CILP SNP is observed in Japanese collegiate athletes.Study Design: Cross-sectional study; Level of evidence, 3.Methods: The participants were 601 trained collegiate athletes (male, 403; female, 198) from 7 different sports. Lumbar disc degeneration was evaluated using T2-weighted magnetic resonance imaging. Genotyping of the CILP gene (1184T/C) was performed by using DNA sequencing.Results: Among the 601 collegiate athletes, the odds ratio (OR) for the occurrence of LDDG with the CILP C allele was 1.4 (95% confidence interval [CI], 1.05-1.86). By using logistic regression analysis concomitant with the interaction term and the Wald test, the authors found that weight (OR, 1.04; 95% CI, 1.02-1.06), CILP genotype (CT: OR, 2.0; 95% CI, 1.24-3.15; CC: OR, 2.9; 95% CI, 1.09-7.74), and gender (OR, 2.1; 95% CI, 1.21-3.67) were significant risk factors for LDDG. These analyses also indicated that there was no effect of the CILP genotype on LDDG in female athletes.Conclusion: The CILP SNP 1184T/C is a risk factor for male collegiate athletes. Information regarding the CILP gene polymorphism may be important for preventing and managing lumbar disc diseases, especially in male athletes.