Roles of Mesenchymal Stem Cell-Derived Exosomes in Cancer Development and Targeted Therapy.
Roles of Mesenchymal Stem Cell-Derived Exosomes in Cancer Development and Targeted Therapy.
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DOI：
10.1155/2021/9962194
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发表时间：
2021
影响因子：
4.3
通讯作者：
Qian H
中科院分区：
文献类型：
--
作者：
Sun Z;Zhang J;Li J;Li M;Ge J;Wu P;You B;Qian H
外泌体已成为一种新型药物递送系统。特别是，源自间充质干细胞（MSCs）的外泌体因其具有肿瘤归巢能力和产量优势而受到广泛研究。鉴于间充质干细胞来源的外泌体在肿瘤的发生、转移和侵袭中具有双刃剑作用，工程化外泌体具有广阔的潜在应用前景。在这篇综述中，我们重点关注了利用工程化和非工程化间充质干细胞来源的外泌体（MSC - EXs）治疗肿瘤的最新进展。非工程化的MSC - EXs通过影响肿瘤生长、血管生成、转移和侵袭，对几种深入研究的肿瘤发挥抗肿瘤作用。此外，工程化外泌体作为携带微小核糖核酸（miRNAs）、小分子药物和蛋白质的载药工具，具有良好的研究前景。尽管外泌体在定义、分离和纯化方面缺乏统一标准，但由于其生物相容性高、毒性低等独特优势，仍具有很高的研究价值。未来关于MSC - EXs的研究应阐明其抗癌作用的潜在机制及其应用的安全性。
Exosomes have emerged as a new drug delivery system. In particular, exosomes derived from mesenchymal stem cells (MSCs) have been extensively studied because of their tumor-homing ability and yield advantages. Considering that MSC-derived exosomes are a double-edged sword in the development, metastasis, and invasion of tumors, engineered exosomes have broad potential use. In this review, we focused on the latest development in the treatment of tumors using engineered and nonengineered MSC-derived exosomes (MSC-EXs). Nonengineered MSC-EXs exert an antitumor effect on several well-studied tumors by affecting tumor growth, angiogenesis, metastasis, and invasion. Furthermore, engineered exosomes have promising research prospects as drug-carrying tools for the transport of miRNAs, small-molecule drugs, and proteins. Although exosomes lack uniform standards in terms of definition, separation, and purification, they still have great research value because of their unique advantages, such as high biocompatibility and low toxicity. Future studies on MSC-EXs should elucidate the mechanisms underlying their anticancer effect and the safety of their application.
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影响因子：
8
作者：
Jia, Yuefeng;Ding, Xuemei;Yang, Xuecheng
通讯作者：
Yang, Xuecheng
DOI：
10.1016/j.nano.2017.03.001
发表时间：
2017-07-01
影响因子：
5.4
作者：
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通讯作者：
Gupta, Ramesh C.
影响因子：
8
作者：
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通讯作者：
Khodashenas, Shabanali
影响因子：
3.4
作者：
Huang, Yao;Liu, Wei;Sun, Luning
通讯作者：
Sun, Luning
间充质干细胞衍生的外泌体对实验性自身免疫性葡萄膜炎的影响
影响因子：
4.6
作者：
Bai L;Shao H;Wang H;Zhang Z;Su C;Dong L;Yu B;Chen X;Li X;Zhang X
通讯作者：
Zhang X