Is cocaine desire reduced by N-acetylcysteine?
Is cocaine desire reduced by N-acetylcysteine?
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N-乙酰半胱氨酸会降低可卡因的欲望吗？
DOI：
10.1176/ajp.2007.164.7.1115
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Malcolm,Robert
中科院分区：
文献类型：
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作者：
LaRowe,StevenD;Myrick,Hugh;Hedden,Sarra;Mardikian,Pascale;Saladin,Michael;McRae,Aimee;Brady,Kathleen;Kalivas,PeterW;Malcolm,Robert
目的动物模型显示N-乙酰半胱氨酸抑制可卡因的寻找。在这项双盲、安慰剂对照试验中，15名参与者在3天的住院期间接受了N-乙酰半胱氨酸或安慰剂。参与者被交换，在4天后的第二次相同的3天逗留中接受相反的情况。在每次住院期间，参与者完成一项线索反应程序，包括收集心理物理和主观数据，以应对描述可卡因和可卡因使用的幻灯片。结果服用N-乙酰半胱氨酸时，参与者报告使用意愿较低，对可卡因幻灯片的兴趣较低，观看可卡因幻灯片的时间较短。结论可卡因线索反应性的抑制与现有的临床前数据一致，支持使用N-乙酰半胱氨酸作为可卡因依赖的治疗方法。
ObjectiveAnimal models suggest thatN-acetylcysteine inhibits cocaine-seeking. The present pilot study evaluated whetherN-acetylcysteine would suppress reactivity to cocaine-related cues in cocaine-dependent humans.MethodIn this double-blind, placebo-controlled trial, 15 participants receivedN-acetylcysteine or placebo during a 3-day hospitalization. Participants were crossed over to receive the opposite condition on a second, identical 3-day stay occurring 4 days later. During each hospital stay, participants completed a cue-reactivity procedure that involved collecting psychophysical and subjective data in response to slides depicting cocaine and cocaine use.ResultsWhile takingN-acetylcysteine, participants reported less desire to use and less interest in response to cocaine slides and watched cocaine slides for less time.ConclusionsThe inhibition of cocaine cue reactivity is consistent with existing preclinical data and supports the use ofN-acetylcysteine as a treatment for cocaine dependence.