Genomic predictors of trainability
Genomic predictors of trainability
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DOI：
10.1113/expphysiol.2011.058735
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发表时间：
2012-03-01
影响因子：
2.7
通讯作者：
Bouchard, Claude
中科院分区：
文献类型：
--
作者：
Bouchard, Claude
运动训练或可训练性反应的个体差异的概念是在30年前定义的。在对一对同卵双胞胎进行的一系列实验研究中，有证据表明，对规律运动的反应能力与基因有很强的相关性。在传统家庭研究中，观察到在调整了年龄、性别、基线最大摄氧量以及基线体重和成分后，20周标准化运动训练的最大摄氧量反应的遗传度达到47%。候选基因研究并没有像最初预期的那样产生许多有效的基因靶点和变种。全基因组的探索产生了更令人信服的关于最大摄氧量可训练性的预测指标。基于21个单核苷酸多态携带的有利等位基因数量的基因组预测分数似乎能够识别至少相差三倍的低和高训练反应类别。结合转录和基因组技术也产生了非常有希望的结果，关于预测久坐的人的可训练性的能力。
The concept of individual differences in the response to exercise training or trainability was defined three decades ago. In a series of experimental studies with pairs of monozygotic twins, evidence was found in support of a strong genotype dependency of the ability to respond to regular exercise. In the HERITAGE Family Study, it was observed that the heritability of the maximal oxygen uptake response to 20 weeks of standardized exercise training reached 47% after adjustment for age, sex, baseline maximal oxygen uptake and baseline body mass and composition. Candidate gene studies have not yielded as many validated gene targets and variants as originally anticipated. Genome-wide explorations have generated more convincing predictors of maximal oxygen uptake trainability. A genomic predictor score based on the number of favourable alleles carried at 21 single nucleotide polymorphisms appears to be able to identify low and high training response classes that differ by at least threefold. Combining transcriptomic and genomic technologies has also yielded highly promising results concerning the ability to predict trainability among sedentary people.