Tinnitus and 2fl-f2 distortion product otoacoustic emissions following salicylate overdose
Tinnitus and 2fl-f2 distortion product otoacoustic emissions following salicylate overdose
复制标题
DOI：
10.1121/1.428578
复制
发表时间：
2000-03-01
影响因子：
2.4
通讯作者：
Arnold, W
中科院分区：
文献类型：
--
作者：
Janssen, T;Boege, P;Arnold, W
一名22岁的女性有自杀意图，服用了大约10克水杨酸盐。她在服药后22小时内出现严重的听力损失和强烈的耳鸣，24小时后听力恢复，耳鸣消失。测量两种状态下的瞬时诱发耳声发射(TEOAEs)和2f1-f2失真产物耳声发射(DPOAEs)。在中毒状态下，DPOAEs可以在与耳鸣出现相对应的频率范围内被很好地记录下来，尽管方位损失为50db。相应的DPOAE I/O函数被线性化，表明外毛细胞压缩的损失。恢复后，DPOAE水平和DPOAE增长均在正常范围内，表现为正常的生理性压迫。TEOAE在急性中毒状态下失踪。这个病例支持阿司匹林引起的耳鸣是在外毛细胞水平上产生的假说。虽然TEOAES只提供了耳蜗内可能发生了变化的证据，但DPOAEs是一些形式的耳蜗性耳鸣潜在机制的更有用和更可靠的量化指标。(C)2000年美国声学学会。[S0001-4966(00)03003-4]。
A 22-year-old woman consumed approximately 10 g of salicylate with suicidal intent. She had a severe hearing loss and a strong tinnitus within 22 h of the overdose, and then 24 h later a subsequent hearing restoration and tinnitus abolishment. Transiently evoked otoacoustic emissions (TEOAEs) and 2f1 - f2 distortion product otoacoustic emissions (DPOAEs) were measured in both states. in the state of intoxication DPOAEs could be recorded well in the frequency range that corresponded to the appearance of the tinnitus despite the 50-dB bearing loss. The corresponding DPOAE I/O-functions were linearized, indicating loss of-outer hair cell compression. After recovery, DPOAE level and DPOAE growth were within the normal range and showed normal physiological compression. The TEOAEs were missing in the acute state of intoxication. This case supports the hypothesis that aspirin-induced tinnitus is generated at the outer hair cell lever. Whereas TEOAEs only give evidence that something might have changed in the cochlea, DPOAEs are a more useful and robust quantitative indicator of the underlying mechanism of some forms of cochlear tinnitus. (C) 2000 Acoustical Society of America. [S0001-4966(00)03003-4].