Exploration of the Impact of Combining Risk Phenotypes on the Likelihood of Alcohol Problems in Young Adults.
Exploration of the Impact of Combining Risk Phenotypes on the Likelihood of Alcohol Problems in Young Adults.
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探索组合风险表型对年轻人酒精问题可能性的影响。
DOI：
10.1093/alcalc/agab049
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Garbutt,JamesC
中科院分区：
文献类型：
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作者：
Kampov-Polevoy,Alexei;Bobashev,Georgiy;Garbutt,JamesC
目的我们检验了高新颖性追求(NS-外化特征)、喜欢甜食(SL-一种可能反映享乐刺激加工的表型)和对酒精损害效应的初始不敏感(SRE-A)独立和协同作用增加青少年出现酒精相关问题的可能性的假设。评定NS、SL和SRE-A，同时进行审计评分和酒精中毒家族史(FH)评定。评估表型及其交互作用对发生酒精问题的可能性的影响。结果这三种表型都对审计总分有贡献。解释审计差异35.8%的最佳模型包括所有三种表型以及NS和SL/甜蜜不喜欢(SDL)状态之间的交互作用。FH的加入解释了两个模型中4%的额外方差。分类和回归树分析表明，影响审计得分的主要表型是NS。SL/SDL表型是高NS的一个强烈的修饰因素。结论多重酒精使用障碍(AUD)风险表型(SL、NS和SRE-A)在个体内具有不同的潜在神经生物学机制，代表着发生酒精相关问题的可能性更高，可能允许对AUD的风险进行分级评估，并为早期干预策略提供可能性。
AimsWe tested the hypothesis that high novelty seeking (NS—an externalizing trait), sweet-liking (SL—a phenotype that may reflect processing of hedonic stimuli) and initial insensitivity to the impairing effects of alcohol (SRE-A) act independently and synergistically to increase the likelihood of having alcohol-related problems in young adults.MethodsA sample of 145 young adults, ages 18–26, balanced for gender and alcohol use disorders identification test (AUDIT) scores <8 or ≥8 were selected from a prior sample. NS, SL and SRE-A were assessed along with AUDIT score and family history of alcoholism (FH). The effect of phenotypes and their interaction on the likelihood of alcohol problems was assessed.ResultsAll three phenotypes contribute to the total AUDIT score. The best-fitting model explaining 35.8% of AUDIT variance includes all three phenotypes and an interaction between NS and SL/sweet-disliking (SDL) status. The addition of FH to the model explains an additional 4% of variance in both models. Classification and regression tree analysis showed that the main phenotype influencing AUDIT score is NS. The SL/SDL phenotype is a strong modifying factor for high NS. SRE-A was shown to be a weak modifier for individuals with low NS.ConclusionThe evidence supports the hypothesis that the presence of multiple alcohol use disorders (AUD) risk phenotypes with different underlying neurobiological mechanisms within an individual (SL, NS and SRE-A) represents a higher likelihood for developing alcohol-related problems and may allow for a graded assessment of risk for AUD and offer the possibility for early intervention strategies.