Metabolic Syndrome in Pediatrics: Old Concepts Revised, New Concepts Discussed
Metabolic Syndrome in Pediatrics: Old Concepts Revised, New Concepts Discussed
复制标题
DOI：
10.1016/j.pcl.2011.07.005
复制
发表时间：
2011-10-01
影响因子：
2.6
通讯作者：
Caprio, Sonia
中科院分区：
文献类型：
--
作者：
D'Adamo, Ebe;Santoro, Nicola;Caprio, Sonia
在过去的几十年里，儿童肥胖症在世界范围内的流行是导致曾经主要在成人中发现的疾病（如代谢综合征）在儿科中发生的原因。代谢综合征发病机制中的一个关键因素是胰岛素抵抗，这种现象主要发生在肥胖受试者中，其对胰岛素仅对碳水化合物代谢的作用具有一般抵抗。鉴于代谢综合征是由肥胖驱动的，后者的患病率将强烈影响代谢综合征的患病率。本文讨论了代谢综合征的原因和肥胖在儿科人群中的相关性。
The worldwide epidemic of childhood obesity in the last decades is responsible for the occurrence in pediatrics of disorders once mainly found in adults, such as the metabolic syndrome. A key factor in the pathogenesis of metabolic syndrome is insulin resistance, a phenomenon occurring mainly in obese subjects with a general resistance to the insulin effect only on carbohydrates metabolism. Given that the metabolic syndrome is driven by obesity, the prevalence of the latter will strongly influence the prevalence of metabolic syndrome. This article addresses the causes of metabolic syndrome and the relevance of obesity in the pediatric population.