Non-Alcoholic Fatty Liver Disease in Older People
Non-Alcoholic Fatty Liver Disease in Older People
复制标题
DOI：
10.1159/000235677
复制
发表时间：
2009-01-01
期刊：
影响因子：
3.5
通讯作者：
Newton, Julia L.
中科院分区：
文献类型：
--
作者：
Frith, James;Day, Christopher P.;Newton, Julia L.
背景：非酒精性脂肪肝（NAFLD）主要是中老年疾病。之前的研究报告称，老年时该病是良性的，但最近的研究表明，60 岁以上的人死亡率会增加。目的：确定危险因素的患病率以及不同年龄组 NAFLD 之间的实验室和组织学差异，以证实/反驳先前小型研究的结果。方法：在英国一家三级肝脏诊所进行的回顾性队列研究。 351 名连续活检证实的 NAFLD 患者被分为老年（≥ 60 岁）、中年（≥ 50 岁至
Background: Non-alcoholic fatty liver disease (NAFLD) is principally a disease of middle and old age. Previous studies reported it to be benign in old age, however more recent studies suggest an increased mortality in the >60-year-olds. Objectives: To define the prevalence of risk factors and the laboratory and histological differences between different age groups with NAFLD, in order to confirm/refute findings in previous smaller studies. Methods: Retrospective, cohort study set in a tertiary liver clinic in the UK. 351 consecutive patients with biopsy-proven NAFLD were divided into an older (>= 60), a middle-aged (>= 50 to