Occurrence and distribution of antibiotic resistance genes in the coastal area of the Bohai Bay, China
Occurrence and distribution of antibiotic resistance genes in the coastal area of the Bohai Bay, China
复制标题
DOI：
10.1016/j.marpolbul.2016.03.064
复制
发表时间：
2016-06-15
影响因子：
5.8
通讯作者：
Zhang, Ying
中科院分区：
文献类型：
--
作者：
Niu, Zhi-Guang;Zhang, Kai;Zhang, Ying
考虑到世界范围内抗生素的滥用，我们调查了渤海湾水体和沉积物中三类抗生素抗性基因（ARG）的丰度以及相应抗生素的浓度。结果显示，所有样本中均检测到了sull和sullI，其丰度范围为10(-5)-10(-2)/16S基因拷贝数。 tetM和ermB的丰度相对高于tet-ARGs和erm-ARGs的其他基因。磺胺类药物是最常见的抗生素，沉积物中抗生素的浓度高于水中的浓度。相关性分析显示抗生素与相应的ARGs具有相关性，表明抗生素在ARGs的产生和转移中发挥着重要作用。回归分析结果表明，I类整合子促进了suit和sulII的增殖和维持。 (C) 2016 Elsevier Ltd. 保留所有权利。
Considering the abuse of antibiotics worldwide, we investigated the abundance of three classes of antibiotic resistance genes (ARGs) and the concentrations of corresponding antibiotics in water and sediments of Bohai Bay. The results showed that sull and sullI were detected in all samples, and their abundance range was 10(-5)-10(-2)/16S gene copies. The abundance of tetM and ermB were relatively higher than the other genes of tet-ARGs and erm-ARGs. Sulfonamides were the most prevalent antibiotics, and the concentrations of antibiotic in sediments were higher than those in water. The correlation analysis revealed that antibiotics had pertinence with corresponding ARGs, indicating that antibiotics play an important role in the creation and transfer of ARGs. The results of regression analysis indicated that the propagation and maintenance of suit and sulIl were facilitated by class I integrons. (C) 2016 Elsevier Ltd. All rights reserved.