BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint.
BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint.
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BACH2-BCL6 平衡调节前 B 细胞受体检查点的选择。
DOI：
10.1016/j.it.2013.11.002
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发表时间：
2014
影响因子：
16.8
通讯作者：
Müschen,Markus
中科院分区：
文献类型：
--
作者：
Swaminathan,Srividya;Duy,Cihangir;Müschen,Markus
在前B细胞受体（BCR）检查点处，选择发育中的前B细胞以成功重排VH-DJH基因区段和表达前BCR。在该检查点降低的严格性可能阻碍具有非功能性B细胞克隆的B细胞库。早期的研究已经描述了通过功能性前BCR激活B细胞淋巴瘤/白血病（BCL）6介导已经通过检查点的前B细胞的阳性选择。现在，最近发现BTB和CNC同源1碱性亮氨酸拉链转录因子2（BACH 2）诱导负选择并在前BCR检查点之前对抗BCL 6功能，进一步阐述了这一概念。在这里，我们讨论了BCL 6和BACH 2之间的拮抗作用在早期B细胞的发展，以及它的影响，在剧目选择和反选择的癌前克隆白血病抑制。
At the pre-B cell receptor (BCR) checkpoint, developing pre-B cells are selected for successful rearrangement of VH–DJHgene segments and expression of a pre-BCR. Reduced stringency at this checkpoint may obstruct the B cell repertoire with nonfunctional B cell clones. Earlier studies have described that activation of B cell lymphoma/leukemia (BCL)6 by a functional pre-BCR mediates positive selection of pre-B cells that have passed the checkpoint. This concept is now further elaborated by the recent finding that the BTB and CNC homology 1 basic leucine zipper transcription factor 2 (BACH2) induces negative selection and opposes BCL6 function prior to the pre-BCR checkpoint. Here, we discuss the antagonism between BCL6 and BACH2 during early B cell development, as well as its implications in both repertoire selection and counter-selection of premalignant clones for leukemia suppression.