Relationship between insulin-like growth factor-I and low-density lipoprotein cholesterol levels in primary hypothyroidism in women.
Relationship between insulin-like growth factor-I and low-density lipoprotein cholesterol levels in primary hypothyroidism in women.
复制标题
女性原发性甲状腺功能减退症中胰岛素样生长因子-I 与低密度脂蛋白胆固醇水平的关系。
DOI：
10.1677/joe.0.1230341
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
J. Birkenhäger
中科院分区：
文献类型：
--
作者：
N. H. D. Linden;Hans Jansen;W. C. Hülsmann;J. Birkenhäger
本文观察了12例原发性甲状腺功能减退症（甲减）患者血清胰岛素样生长因子-Ⅰ（IGF-I）对脂代谢紊乱的影响。观察到低密度脂蛋白（LDL）胆固醇和中密度脂蛋白胆固醇显著增加。用甲状腺素（T4）替代后，脂蛋白浓度恢复正常，直至达到甲状腺功能正常状态。甲状腺功能减退患者IGF-I降低65%（P <0.005），与LDL胆固醇浓度呈负相关（r = -0.75; P <0.01）。LDL胆固醇对IGF-I和游离T4的多变量回归分析表明，IGF-I决定LDL胆固醇的浓度，而不是游离T4。我们的数据表明，在甲状腺功能减退症中，IGF-I是LDL胆固醇浓度的决定因素。此外，甲状腺功能减退症可通过降低抗盐脂肪酶（肝脂肪酶）的活性来影响血浆脂蛋白代谢。
The effect of insulin-like growth factor-I (IGF-I) on the disturbance of lipid metabolism during primary hypothyroidism was studied in 12 women with primary hypothyroidism. Significant increases in both low-density lipoprotein (LDL) cholesterol and intermediate-density lipoprotein cholesterol were seen. Lipoprotein concentrations reverted to normal after substitution with thyroxine (T4) until the euthyroid state was reached. A decrease in IGF-I of 65% (P less than 0.005) was seen in hypothyroid patients and this was inversely correlated (r = -0.75; P less than 0.01) with the concentration of LDL cholesterol. Multivariate regression analysis of LDL cholesterol against IGF-I and free T4 showed that IGF-I determines the concentration of LDL cholesterol instead of free T4. Our data suggest that in hypothyroidism, IGF-I is a determinant of the concentration of LDL cholesterol. In addition, hypothyroidism can influence plasma lipoprotein metabolism by lowering the activity of the salt-resistant lipase (liver lipase).