Micturition in conscious rats with and without bladder outlet obstruction: role of spinal α1‐adrenoceptors
Micturition in conscious rats with and without bladder outlet obstruction: role of spinal α1‐adrenoceptors
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有或没有膀胱出口梗阻的清醒大鼠的排尿：脊髓 α1 肾上腺素受体的作用
DOI：
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发表时间：
1996
影响因子：
7.3
通讯作者：
K. Andersson
中科院分区：
文献类型：
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作者：
O. Ishizuka;K. Persson;A. Mattiasson;A. Naylor;Michael G. Wyllie;K. Andersson
1在正常大鼠和继发于流出道梗阻的膀胱肥大大鼠中，进行连续膀胱测压，我们检查了对鞘内（i.t.）给予选择性α1肾上腺素受体拮抗剂多沙唑嗪的反应。和动脉内（i.a.）。此外，我们研究了药物对正常无阻塞大鼠中左旋多巴诱导的膀胱过度活动的影响。2多沙唑嗪50 nmol（约60 μg kg−1），i.t.给药，正常大鼠和梗阻后膀胱肥大动物的排尿压降低。这种效应在膀胱肥大/过度活动的动物中更为明显。多沙唑嗪对梗阻大鼠不稳定收缩的频率和幅度无明显影响。然而，相比之下，多沙唑嗪减少了L-多巴诱导的膀胱过度活动。当测试时，多沙唑嗪的对映体产生与多沙唑嗪定性相似的作用，但没有立体选择性的证据。3结果表明，除了对前列腺和下尿路平滑肌的作用，以及对膀胱、膀胱颈、前列腺和尿道外括约肌的交感神经流出的作用外，多沙唑嗪可能在脊髓和神经节水平上起作用，从而降低膀胱副交感神经的活动。这种效应在膀胱肥大大鼠中比在正常大鼠中更明显。
1 In normal rats and rats with bladder hypertrophy secondary to outflow obstruction, undergoing continuous cystometry, we examined the responses to the selective α1‐adrenoceptor antagonist doxazosin given intrathecally (i.t.) and intra‐arterially (i.a.). In addition, we investigated the effects of the drug on L‐dopa‐induced bladder hyperactivity in normal, unobstructed rats. 2 Doxazosin 50 nmol (approximately 60 μg kg−1), given i.t., decreased micturition pressure in normal rats and in animals with post‐obstruction bladder hypertrophy. The effect was much more pronounced in the animals with hypertrophied/overactive bladders. Doxazosin did not markedly affect the frequency or amplitude of the unstable contractions observed in obstructed rats. In contrast, however, doxazosin reduced L‐dopa‐induced bladder overactivity. When tested, the enantiomers of doxazosin produced qualitatively similar effects to doxazosin, but there was no evidence of stereoselectivity. 3 The results suggest that in addition to the well documented action on prostatic and lower urinary tract smooth muscle, and an effect on the sympathetic outflow to the bladder, bladder neck, prostate, and external urethral sphincter, doxazosin may have an action at the level of the spinal cord and ganglia, thereby reducing activity in the parasympathetic nerves to the bladder. This effect is more pronounced in rats with bladder hypertrophy than in normal rats.
影响因子：
6.6
作者：
STERNBERG, CN;YAGODA, A;WHITMORE, WF
通讯作者：
WHITMORE, WF