ACTIVATION OF PP60C-SRC PROTEIN-KINASE ACTIVITY IN HUMAN-COLON CARCINOMA
ACTIVATION OF PP60C-SRC PROTEIN-KINASE ACTIVITY IN HUMAN-COLON CARCINOMA
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DOI：
10.1073/pnas.84.8.2251
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发表时间：
1987-04-01
影响因子：
11.1
通讯作者：
ROSEN, N
中科院分区：
文献类型：
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作者：
BOLEN, JB;VEILLETTE, A;ROSEN, N
从人结肠癌组织和肿瘤来源细胞系中获得的pp60c-src分子的酪氨酸特异性蛋白激酶活性被发现高于正常结肠组织或正常结肠粘膜细胞培养物。肿瘤组织和培养的结肠癌细胞中pp60c-src蛋白激酶活性的升高似乎并不仅仅是因为c-src编码蛋白丰度的增加，这表明pp60c-src酪氨酸磷酸转移酶的特异性活性增强了。这些结果提高了pp60c-src蛋白激酶的激活可能有助于人类结肠肿瘤的发生的可能性。
The tyrosine-specific protein kinase activity of pp60c-src molecules obtained from human colon carcinoma tissues and tumor-derived cell lines was found to be elevated over that from normal colon tissues or cultures of normal colon mucosal cells. The elevated pp60c-src protein kinase activity in tumor tissues and in cultured colon carcinoma cells does not appear to result solely from an increase in the abundance of the c-src-encoded protein, suggesting that the specific activity of the pp60c-src tyrosine phosphotransferase is enhanced. These results raise the possibility that activation of the pp60c-src protein kinase may contribute to the genesis of human colon tumors.