Mutations associated with in vitro resistance to bedaquiline in Mycobacterium tuberculosis isolates in Australia
Mutations associated with in vitro resistance to bedaquiline in Mycobacterium tuberculosis isolates in Australia
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DOI：
10.1016/j.tube.2018.04.007
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发表时间：
2018-07-01
期刊：
影响因子：
3.2
通讯作者：
Sintchenko, Vitali
中科院分区：
文献类型：
--
作者：
Martinez, Elena;Hennessy, Daneeta;Sintchenko, Vitali
对来自澳大利亚新南威尔士州的 517 株结核分枝杆菌分离株进行全基因组分析，发现了先前报道的 Rv0678 和 atpE 基因中的 8 个新突变，这些突变与贝达喹啉（一种新型抗分枝杆菌药物）的体外耐药性有关。这些突变存在于 2.9% 的前瞻性测序基因组中，但存在于 10.6% 的表型多重耐药菌株中。然而，只有 14% 具有这些突变的分离株表现出贝达喹啉的最低抑制浓度升高。
Genome-wide analysis of 517 Mycobacterium tuberculosis isolates from New South Wales, Australia, have identified previously reported and 8 new mutations in Rv0678 and atpE genes linked to in vitro resistance to bedaquiline, a new class of antimycobacterial drugs. These mutations were present in 2.9% of prospectively sequenced genomes but in 10.6% of strains that were phenotypically multidrug-resistant. However only 14% of isolates with these mutations demonstrated elevated minimum inhibitory concentrations to bedaquiline.