ULTRASTRUCTURAL-STUDY OF CERVICAL GONORRHEA
ULTRASTRUCTURAL-STUDY OF CERVICAL GONORRHEA
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DOI：
10.1093/infdis/136.2.248
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发表时间：
1977-01-01
影响因子：
6.4
通讯作者：
EVANS, BA
中科院分区：
文献类型：
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作者：
EVANS, BA
本文对淋病奈瑟菌感染患者宫颈鳞状柱状交界处进行了超微结构观察。淋球菌变得牢固地附着在复层鳞状上皮上，这一过程似乎是由表层鳞片的细胞质膜活动启动的。淋球菌不附着于分泌粘液的柱状上皮，甚至不与之密切相关。淋球菌的生长在宫颈分泌物中最活跃，主要是在剥落的鳞片上，但也是自由的，这一点从微生物数量和表面囊泡的形成中得到了证明。中性粒细胞吞噬后的存活并不是淋球菌独有的，持续的吞噬循环可能会将这种情况的重要性降至最低。淋病在女性中的持久性可能取决于淋球菌与复层上皮的黏附，在那里它们被保护不被吞噬，而淋病的传染性源于淋球菌在剥落的鳞片表面迅速分裂的能力，从那里它们被释放到分泌物中。
An ultrastructural examination of the squamocolumnar junction of the cervix of patients infected with Neisseria gonorrhoeae, is described. Gonococci became firmly attached to stratified squamous epithelium, a process that appeared to be initiated by activity of the cytoplasmic membrane of supeficial squames. Gonococci were not attached to, or even closely associated with, mucus-secreting columnar epithelium. Gonococcal growth, as evidenced by numbers of organisms and surface vesicle formation, appeared most active in cervical secretions, chiefly on exfoliated squames, but also lying free. Survival after phagocytosis by polymorphonuclear leukocytes was not unique to gonococci, and continual phagocytic recycling may minimize the significance of this occurrence. Persistence of gonorrhea in the female probably depends on the adherence of gonococci to stratified epithelium, where they are protected from phagocytosis, and the infectivity of gonorrhea arises from the ability of gonococci to divide rapidly on the surface of exfoliated squames, from where they are released into secretions.