Age-related differences in movement representation
Age-related differences in movement representation
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DOI：
10.1006/nimg.2002.1309
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发表时间：
2002-12-01
期刊：
影响因子：
5.7
通讯作者：
Schlaug, G
中科院分区：
文献类型：
--
作者：
Hutchinson, S;Kobayashi, M;Schlaug, G
重复运动已被用作各种神经系统疾病的研究中的运动激活任务。为了确定年龄匹配的对照组在这些研究中的重要性，我们调查了在简单重复运动过程中看到的皮层激活模式是否存在显著的年龄相关变化。研究了16名右利手的健康受试者-8名年轻人和8名老年人。功能性磁共振图像采集，而受试者进行运动任务或非运动休息条件。两个连续的运动任务，食指外展/内收和腕关节伸展/屈曲，由每只手进行，使用节拍器起搏。用SPM '99软件对fMRI数据进行处理和分析。对于组间比较，对于每个运动任务，对侧初级感觉运动皮层和运动前皮层在年轻组中具有显著更大的激活，而尾部补充运动区在老年组中具有显著更大的激活。老年组同侧感觉运动皮层在双手食指运动任务中激活更显著。老年组中所有注意到的差异在食指运动方面更为突出，在使用非优势手时最为突出。总之，与重复运动相关的激活模式存在显着的年龄相关差异。这可能代表了老年受试者运动皮层单位的补偿性募集，因为老年组在更困难的运动任务（孤立的手指运动和非优势手使用）中存在较大的差异。这项研究对老年人神经系统疾病的功能成像实验具有重要意义。(C)2002 Elsevier Science（美国）。
Repetitive movements have been used as motor activation tasks in the investigation of various neurological disorders. To determine the importance of an age-matched control group in such studies we investigated whether there are significant age-related changes in the pattern of cortical activation seen during simple repetitive movements. Sixteen right-handed healthy subjects were studied-8 young and 8 old. Functional magnetic resonance images were acquired while subjects performed a motor task or a nonmovement rest condition. Two continuous motor tasks, index finger abduction/adduction and wrist extension/flexion, were performed by each hand, paced using a metronome. The fMRI data were processed and analyzed with SPM '99. For the between-group comparisons, for each motor task, contralateral primary sensorimotor cortex and premotor cortex had significantly greater activation in the Young group and caudal supplementary motor area had significantly greater activation in the Old group. Ipsilateral sensorimotor cortex was more significantly activated in the Old group for index finger motor tasks of both hands. All noted differences in the Old group were more prominent for the index finger movement and most prominent when using the nondominant hand. In conclusion, there are significant age-related differences in the activation pattern associated with repetitive movements. This may represent compensatory recruitment of motor cortical units in the older subjects as larger differences are noted in the older group during the more difficult motor tasks, those of isolated finger movement and nondominant hand use. This study has important implications for functional imaging experiments of neurological disorders in older subjects. (C) 2002 Elsevier Science (USA).