Early recognition of benign partial epilepsy in infancy
Early recognition of benign partial epilepsy in infancy
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DOI：
10.1111/j.1528-1157.2000.tb00233.x
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发表时间：
2000-06-01
期刊：
影响因子：
5.6
通讯作者：
Watanabe, K
中科院分区：
文献类型：
--
作者：
Okumura, A;Hayakawa, F;Watanabe, K
目的：本研究的目的是确定如何准确地认识到在婴儿癫痫开始在第一年的生命。方法：我们进行了一项前瞻性的5年随访研究63例癫痫患者在第一年的生活。我们首先判断患者在入组本研究时符合“婴儿期可能良性部分性癫痫（BPEI）”的标准。在2岁时，我们重新评估了被诊断为“可能BPEI”的患者的癫痫发作和发育结果。“我们最终判断患者在5岁时符合“明确BPEI”的标准。“可能的BPEI”定义为符合以下所有条件的癫痫：（a）复杂部分性癫痫发作和/或继发性全身性癫痫发作;（B）发作前精神发育和神经学检查结果正常;（c）发作间期脑电图正常;（d）头颅计算机断层扫描（CT）和磁共振成像（MRI）检查结果正常，以及（e）出生后前4周内无癫痫发作。“明确BPEI”定义为除符合“可能BPEI”的标准外，还符合以下所有标准的癫痫：（a）5岁以上精神发育正常，（B）2岁以上无癫痫发作。32例患者中有25例完成了5年随访。在2岁时，4名患者因癫痫复发和/或发育延迟而被排除在“可能的BPEI”组之外。到5岁时，一个癫痫复发，另一个表现出轻度延迟的精神发育。我们最终诊断为19例患者有“明确的BPEI”，“明确的BPEI”占76%的患者诊断为“可能的BPEI”在第一次介绍和90%的那些谁符合条件的重新评估在2岁。结论：承认BPEI是可能的，在一定程度上，在第一次介绍，并重新评估在2岁是有用的一个更精确的诊断。
Purpose: The aim of this study is to determine how precisely we can recognize the outcome in infants with epilepsy beginning in the first year of life.Methods: We performed a prospective 5-year follow-up study on 63 patients who developed epilepsy in the first year of life. We first judged that patients met the criteria of "possible benign partial epilepsy in infancy (BPEI)" on enrollment in this study. At 2 years of age, we reevaluated the seizure and developmental outcome in the patients who were diagnosed as having "possible BPEI." We finally judged that patients met the criteria of "definite BPEI" at age 5 years. "Possible BPEI" was defined as epilepsy meeting all the following conditions: (a) complex partial seizures and/or secondarily generalized seizures; (b) normal psychomotor development and neurologic findings before onset; (c) normal interictal electroencephalograms; (d) normal cranial computed tomography (CT) and magnetic resonance imaging (MRI) findings, and (e) no seizures during the first 4 weeks of life. "Definite BPEI" was defined as epilepsy meeting all the following criteria in addition to those of "possible BPEI": (a) normal psychomotor development beyond age 5 years, and (b) no seizures beyond age 2 years.Results: Thirty-two of the 63 patients met the inclusion criteria completely and were included in the "possible BPEI" group. Twenty-five of the 32 patients completed the 5-year follow-up. At age 2 years, four patients were excluded From the "possible BPEI" group because of seizure recurrence and/or delayed development. By age 5 years, one had a recurrence of seizures, and another exhibited mildly delayed psychomotor development. We finally diagnosed 19 patients as having "definite BPEI," "Definite BPEI" accounted for 76% of the patients diagnosed as having "possible BPEI" at the first presentation and 90% of those who met the conditions on reevaluation at age 2 years.Conclusions: Recognition of BPEI is possible, to some extent, at the first presentation, and reevaluation at age 2 years is useful for a more precise diagnosis.